Lisa walks in the school cafeteria at West Boulder High and is very angry with Zack because he mooned her and her family when they were going to a funeral. Zack and Ted both try to explain that Zack thought he was mooning Ted, because he does it all the time. Lisa does not care and tells Zack she never wants to see him again, which she tells him in every episode.
At Zack's house, Zack makes out with a girl named Shannon, who has a huge reputation about being very "easy." Shannon tells Zack she only will go further if he is over Lisa and Zack says he is. When Zack begins kissing her neck, Shannon begins to moan and then Zack makes a huge mistake. "Oh Lisa" comes out his mouth and upsets Shannon and when she discovers Zack does not even know her name, that causes her to leave. The next day at the Down Hill Dinner, JC and Gilby are talking and Gilby tells JC that he needs to get a car so he can get some girls, or should I say girls his age and not older woman? Gilby tells JC about a website where you can a get a free car and JC jumps at the chance. Zack walks in proclaiming that his private part is burning and he is afraid he has VD. He begins to wonder because he did not do it with Shannon and then he remembers using the toilet at school after a big guy named Stottlemeyer used it before him. Ted walks in and asks whats going on and the guys say no because he tells Nancy everything and Nancy would tell Lisa. Ted says he would not and he would give them $1,000 if they said what was going on and JC and Gilby both tell him at the same time that Zack has VD.
A girl named Leanne overhears JC and Gilby talking about the vehicle he is getting and Leanne wants to go out with JC. The date is set and now the vehicle shall arrive. When the vehicle arrives, JC flips because it is a Maxi Fresh van, and the Maxi Fresh part explain it. JC covers the advertisements on the van up with tape, but the tape flies off on the road. Meanwhile, Zack is still suffering from the burn and is afraid he really may have VD. Ted and Nancy is making out and Nancy finds out that there is something wrong with Zack and Ted refuses to tell so he would not have to give JC and Gilby $1,000 (the deal was, if he told Nancy, he had to hand over the money) and Nancy adds 6 months to the wait of them having sex.
On Nancy and Ted's next date, Nancy tries to get Ted to confide into her with whats going on with Zack. Nancy knows that Zack is sick in some form and she guesses what it could be. When she gets down to Zack's waist (she is guessing what part of the body the sickness has to do with) and Ted thinks she is talking about Zack's private part and tells Nancy not to say anything. Nancy believes Zack needs a kidney transplant and she tells Lisa. Lisa freaks out and she finds Zack to tell him she did not mean any of the mean things she said to him and she hopes Zack will be ok. Lisa never comes out and mentions a kidney transplant, which makes Zack think that she really knows that he may have VD, when she does not have a clue. Zack schedules to have a test done to see if he has VD. Female Dr. Burns comes in to give Zack the test and Zack passes out in the nude.
At the Down Hill Dinner, Zack is waiting patiently with the guys for the results of the test. Zack calls the doctor's office and cannot make out what their saying. Zack is practically screaming into the phones mic and when he discovers the results were negative and it was only a temporary thing, Zack screams out over and over that he does not have VD. Everyone in the Down Hill Dinner claps for him. When Zack is screaming out that he does not have VD, Lisa walks in to hear it. She is very angry because she thinks Zack made up a lie about have a kidney transplant so it would get back to her and she would feel sorry for him. Zack is clueless and has no idea what is going on and thought Lisa knew about the VD thing. The guys tell Lisa about how Zack thought he got it from Shannon or Stottlemeyer, Lisa gets angry because she thinks Zack slept with Shannon and Zack tries to explain, but Lisa is already out the door. Just another episode airing with an angry Lisa, all because of Zack's Little Problem.