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Jackie gets fired when Cruz pushing her to her wits end; The Staff protests but it is too late; Gracie gets enrolled into public school; Jackie has to deal with a pregnant O'Hara and Charlie entering the ER.
Jackie takes charge of the E.R. after many of her colleagues are fired and the waiting room is flooded with patients redirected from another hospital. Cruz suffers a pulmonary episode after being very stressed and Coop admits him to the hospital.
Kevin comes to the hospital to talk with Jackie about the drugs he found in Grace's backpack. Ike tells Zoey they need to keep their relationship from the staff at the hospital. Coop accuses Carrie of sleeping with Ike in order to get what she wants.
A day before her birthday, Jackie tries to convince her estranged husband to let their kids spend the day with her. Meanwhile, a bus accident floods the ER with emergency patients, Eddie gets his old job back and O'Hara reveals that she wants to spend more time with her newborn son.moreless
In a moment of carelessness, Jackie rear-ends Kevin just after having come to an agreement in their custody meeting. When she wakes up in her own ER, Kevin accuses her of using again. An admirer asks her out on a date.
Jackie is nervous about her first post-divorce date with Frank and seeks Zoey and Thor's help. Mike Cruz reappears and interrupts her date. At the hospital, Gloria and Coop catch a mistake Dr. Prentiss made and a rebellious act gets Grace into trouble.
Jackie deals with her family issues as she prepares for her one year of sobriety. Gloria is threatened with a lawsuit by Carrie's lawyer, if she doesn't keep on staff at All Saint's. Ike decides to keep his relationship with Zoey a secret indefinitely. Jackie and Frank patch things up.
Jackie's drug habits get everyone in trouble.
When Jackie leaves a Jane Doe with a drug overdose in Gloria's care, the patient goes missing and Jackie realizes Gloria is dealing with memory issues. Meanwhile, Coop tries to go out with Carrie and Jackie's daughters act out.
Jackie seeks advice to fight Kevin's demands and get her children back. Meanwhile, Dr. Cruz suffers from a panic attack at the hospital and Jackie makes a surprising discovery about Charlie.
After breaking up with Kevin, Jackie has to realize she needs professional help. Meanwhile, a new director at the hospital makes some personnel changes and Kevin finds out about Jackie and Eddie's affair.
A psych patient ravages the pharmacy because Akalitus forgot to get the patient an escort, and Eddie and Jackie decide they need to find out what's wrong with Gloria. Zoey finds a way to change Dr. Prentiss's awful bedside manner, and Coop gives up mentoring Carrie after she misses an appendicitis. Frank cancels a lunch date with Jackie to pick up an extra shift and has her scared to death when a call about a cop being shot comes in.moreless
Jackie and Kevin punish Gracie for her constant lying and sneaking off. Ike deals with a patient suffering from PTSD. Jackie and Mike Cruz say goodbye to each other, as he does his exit interview from All Saint's. Carrie finally discovers her kink while dealing with an out bursting man that was brought into Emergency.moreless
Kevin interrrupts Jackie and Frank's date night. Gloria's blood test gives the answer to her recent memory issues. Zoey helps Ike organize his office. Jackie gets angry with Grace when she finds out she left campus for lunch. Frank asks Jackie to deal with her problems.
Jackie is surprised when what she thinks is a simple lunch with Kevin turns out to be the start of a divorce.
Going through rehab, Jackie opens up about the beginning of her addiction. Meanwhile, Coop is the only one being excited about Cruz's ideas.
A Percocet pill tempts Jackie, especially when she finds out Kevin is suing for child support and her house. Meanwhile, Zoey loses her engagement ring and Coop longing for a family is determined to fill in the role of the father for O'Hara's unborn child.
When Grace finds out about Jackie's stay in rehab, Jackie comes clean to Kevin. Charlie has Jackie worried when he shows up drunk at an AA meeting.
Kevin tells Jackie he'll agree to shared custody if she changes her hours at the hospital. Coop continues to make a play for Dr. Roman. Zoey surprises Jackie by bringing Grace and Fiona to her house and having a party and Dr. O'Hara sends birthday greetings via web cam. Gloria makes Ike the new chief of the E.R.moreless
Jackie decides to leave rehab early to reconcile with her daughter. Back at work, she soon finds out that being sober makes it way more difficult to deal with the stress of her job.