Jackie gets fired when Cruz pushing her to her wits end; The Staff protests but it is too late; Gracie gets enrolled into public school; Jackie has to deal with a pregnant O'Hara and Charlie entering the ER.
Jackie takes charge of the E.R. after many of her colleagues are fired and the waiting room is flooded with patients redirected from another hospital. Cruz suffers a pulmonary episode after being very stressed and Coop admits him to the hospital.
Jackie's drug habits get everyone in trouble.
Jackie seeks advice to fight Kevin's demands and get her children back. Meanwhile, Dr. Cruz suffers from a panic attack at the hospital and Jackie makes a surprising discovery about Charlie.
A Percocet pill tempts Jackie, especially when she finds out Kevin is suing for child support and her house. Meanwhile, Zoey loses her engagement ring and Coop longing for a family is determined to fill in the role of the father for O'Hara's unborn child.
Jackie is surprised when what she thinks is a simple lunch with Kevin turns out to be the start of a divorce.
When Grace finds out about Jackie's stay in rehab, Jackie comes clean to Kevin. Charlie has Jackie worried when he shows up drunk at an AA meeting.
Jackie decides to leave rehab early to reconcile with her daughter. Back at work, she soon finds out that being sober makes it way more difficult to deal with the stress of her job.
Going through rehab, Jackie opens up about the beginning of her addiction. Meanwhile, Coop is the only one being excited about Cruz's ideas.
After breaking up with Kevin, Jackie has to realize she needs professional help. Meanwhile, a new director at the hospital makes some personnel changes and Kevin finds out about Jackie and Eddie's affair.