Someone has just arrived in Tree Hill: Cooper, Nathan's uncle, who is Deb's younger brother. Actually, Deb asked Cooper to come and visit Nathan, since she is very worried about her son. Uncle Cooper takes Nathan and Lucas on a racing trip, where they meet Daytona and her know-it-all brother, Jarret. Daytona and Jarret challenge Nathan and Lucas to a race. Meanwhile, Dan shows up at Andy's class and purposely blurts out that Andy and Karen are dating. As soon as the Dean learns of the affair, he presents Andy with two options. "Either I end the relationship or I lose my job."
Brooke is worried about Peyton since she can't seem to get over Jake, so Brooke decides it's time they had a girls' night. The two friends spend a nice evening at Tric, with Karen and Deb. Aso having a nice night out are Mouth and Erica, who wind up kissing at the end of the night.
The next day, Dan finds Deb sleeping on the lawn. Yep, it turns out her addiction to pain pills has been intensifying lately. At the same time, Nathan loses control of his car and crashed into a wall. As soon as Deb tells Dan they can't share the same house anymore, a phone rings: it's about Nathan.
Meanwhile, Whitey drops in to visit Peyton. Even though Jake doesn't want her to visit him in prison -since it's too heartbreaking - he wants her to know that Jenny is safe and fine.
At the hospital Deb, Dan, and Lucas learn that Nathan's lung collapsed: the boy needs emergency surgery. Before going, Nathan tells Lucas not to inform Haley about what happened to him. Lucas is stunned. How can he possibly keep her husband's accident a secret from his best friend?