Goof: When Dan is admitting to the audience that he is, in fact, a murderer, the clock behind him counts from 65 two times.
The conversation that Lucas has with Peyton when she is still unconscious about the baby not yet having a name mirrors the same conversation he had with Karen about Lily when Karen was in a coma in "All of a Sudden I Miss Everyone".
The NBA team that calls Nathan, the Charlotte Bobcats, is the team that Nathan and Lucas went on a road trip to see in Season 2's "Truth, Bitter Truth".
Jamie and Sawyer's names were arranged the same way. James and Sawyer are the last names of their mothers, Lucas and Brooke are their moms' best friends' names, and both of them have the same last name, Scott, after their fathers.
While discussing Nick Lachey, Julian mistakenly says that Nick starred on the show Laguna Beach. Chase then replies that it was "some other tool." Stephen Colletti, the actor who plays Chase, actually starred in the first season of Laguna Beach.
Being that Chuck is kind of a Tim Smith character it made total sense when Skills announced he had been "Chucked" because they were "Timmed" a few times through out his run on the show.
Samantha becomes the girl behind the red door when she moves in with her birth mother. Brooke, her foster mother, was the girl behind the red door when she was in high school. First at her parents' house and then when Lucas painted his door for her when she moved into his mother's house. Last of all in high school she was the girl in the red bedroom when she and Peyton painted their room red to reclaim Peyton's security.
Note: Brooke was also the girl behind the red door when she lived in the apartment at the beginning of season 3 and the end of season 4.
Goof: In the flashback scene in Peyton's car when Lucas gives Peyton the tickets to The Cure concert, the water behind Lucas doesn't move. The scene was obviously shot against a background instead actual water.
When Lucas has the flashback of giving Peyton the tickets for The Cure concert, it was supposed to be the day after the events that took place in the season four finale. However, Peyton's hair is noticeably longer and Lucas' hair is noticeably shorter than in the Season 4 finale: in effect, they look exactly as they do now.
When Haley tells Peyton she "totally thudded" her, she is referring to when Lucas turned in Peyton's sketches to Thud magazine in season 1 episode 3, "Are You True?"
Being that Chuck is kind of the Tim Smith character for the kids it made sense that his basketball number was 0 just like Tim's starting with season 3.
Brooke says that the last boy she loved was Lucas. But in Episode 4.20 she tells Chase she loves him.
Although credited, Antwon Tanner (Antwon "Skills" Taylor) does not appear in this episode.
When Brooke and Peyton are in shop with Missy, Missy said exactly the same words as Brooke said to Peyton in episode 6 season 1: [i]Wanna know what I think? I think Nathan likes tutor girl. But I think tutor girl likes Lucas. And I know I like Lucas. And I don't know who the hell you like anymore. This is all turning into one big love ...rectangle plus one, whatever that is.[/i] but she can't possibly know the exact quote of Brooke words neither do Lucas who wrote the script.
During the scene between Dan and Nathan at the river court, there appears to be sun on both of their faces when the shot is from behind Nathan. However, when the shot changes to behind Dan both of their faces are in the shade.
One of the movies Lucas and Peyton rent for Jamie and Andre to watch is "Trouser Hound" which was featured on the wall of Adam Reece's office in episode 6.12 "You Have to Be Joking (Autopsy of the Devil's Brain)."
When we see Mouth throwing darts at the picture of Owen, there are three darts on the dart board/picture. He then proceeds to throw two more darts, while Brooke throws one. But when we look at the dart board/picture again it shows only three darts. Assuming they all hit the board, which we hear from the sound, there should be six darts on the board.
B.J. Britt (Devon) has appeared on One Tree Hill before. He played the referee during the basketball game in Episode 1x6. However, it's not unlikely that this is actually Devon.
James van der Beek, who starred as the movie director in this episode, also played the title role in Dawson's Creek, as Dawson Leery, whose directorial ambitions finally come to fruition in the last season. Interestingly, that show was shot in Wilmington N.C., the same place that One Tree Hill currently films.