Brain: Pinky, are you pondering what I'm pondering?
Pinky: I think so, Brain, but "instant karma" always gets so lumpy.
This episode marks Snowball's last appearance; coincidentally, his voice actor, Roddy MacDowall, died of a heart attack shortly after this episode aired.
Animation by Rough Draft Studios, Inc.
This cartoon was first aired as part of episode 64. The gag credit for this episode is: Viraginity - Female masculinity.
The title is a nod to the name of the film Die Hard 2: Die Harder.
When Bob says to Precious "Kitty, I think this is the beginning of a beautiful friendship", this is a nod to the famous final line of the film Casablanca, "Louis, I think this is the beginning of a beautiful friendship."
This episode features several references to Marlon Brando movies:
-Dr. Mordough is physically based on Brando, who played the title role in the 1996 film version of H.G. Wells' The Island of Dr. Moreau. Like Mordough, Moreau was also a geneticist interested in gene splicing and DNA experimentation.
-Snowball claims that he sent his lawyers to Mordough's island, and they were never seen again. They are later found brainwashed. This is a reference to Apocalypse Now, in which Brando plays the renegade Colonel Walter Kurtz; several people sent to find Kurtz mysteriously disappeared, only to be discovered, now loyal to the Colonel.
-The scene is which Mordough sticks an orange wedge in his mouth is an homage to The Godfather; Don Vito Corleone (played by Brando) plays a similar game with his grandson just before dying.
-In another Godfather reference, Mordough says "I'll make the world a fruit salad it can't refuse," a take-off of Don Vito's line, "I'm gonna make him an offer he can't refuse."