The song Pinky is singing in the bar is to the tune of the song he was singing in Animaniacs episode "Spellbound".
This cartoon was first aired as part of episode 14. The gag credit for this episode is: Peritoneum = The membrane that lines the abdominal cavity.
Brain's false earth, 'Chia World', is a play on the popular pottery gift Chia Pets.
Though not mentioned by name, the paper mache Sphinx that Pinky makes is a take on the comic strip cat Garfield.
The character of Mama Strutt is a parody of TV personality Martha Stewart.
Classical music on the soundtrack: Dvorak, Symphony No. 9, "From the New World" (appropriate since the Brain was creating a new world).