I loved Pinky and The Brain. One of the best shows of the 1990s.
Pinky and The Brain are, as it's wonderful theme song says, "two laboratory mice whose genes have been spliced". The Brain lives up to his name and has a giant brain and a genius intellect. Pinky, on the hand, is more on the mentally challenged side of things. Every night they try, and fail, to take over the world with one The Brain's evil genius plans.
Pinky and The Brain started off just a recurring bit in the Animaniacs, which was also a great show, but there was so much potential in the concept that Pinky and The Brain soon had their own show.
The Brain's voice was a perfect mock Orson Welles and Pinky's nonsensical rantings and noises were hilarious. But the single best part was the theme song. The Pink and The Brain theme song will go down as one of the best theme songs of all time. It's impossible to be unhappy while listening to that song.