Stuart Damon (Alan), Leslie Charleson (Monica), Brad Maule (Tony) and John J. York (Mac), cross over from General Hospital for the pilot episode of the spin-off series.
Kin Shriner (Scott), a former General Hospital regular, reprises his former role in this episode. He last appeared on GH as Scott on December 22, 1993 and makes his first return as Scott in this episode.
Jennifer Hammon reprises the role of Karen Wexler, a former General Hospital character (previously played by Cari Shayne), in this episode.
Rachel Ames (Audrey), the longest-running General Hospital cast-member at this time, appears in the pilot and subsequent episodes and is credited as regular on Port Charles while subsequently continuing her role on GH.
Lynn Herring (Lucy) and Jon Lindstrom (Kevin) transplant their General Hospital characters to the spin-off series in this episode.
The spin-off series of General Hospital officially began with this episode- a 2-hour TV-movie that aired on Sunday, July 1, 1997 at 9:00 p.m. The series would move to its regular timeslot the following day.