Dr Collette's best friend returns to San Fransisco and learns that there is a strong chance her cancer has returned, even though there is very little evidence of a tumour. Jackie encourages her to participate in chemotheraphy to be safe rather than sorry. But the chemotherapy has an adverse effect on her system and she admitted to the hospital. Treated by Dr. Brennan, Dr Lanning and Dr Kokoris all of whom fail to understand what is wrong as her health decreases. Leaving Dr Collette useless on the sidelines making her question her career is Plastics. As her situation worsen's a commission is held by the hospital to discover what went wrong in her treatment. And when nothing is discovered, all doctors work towards finding the cure. Meanwhile Jackie's realtionship with Dr. Boyd is taken to the next level.