While the riot intensifies, Abruzzi and Sucre join forces. Michael must decide whether or not to save the life of Dr. Tancredi.
Abruzzi struggles to get his crew back to PI. He tries to convince Michael to reveal Fibonacci's whereabouts to Falzone.
Agents Kellerman and Hale receive some professional help for their search, as the Vice President isn't satisfied about their progress so far.
An inmate becomes suspicious of the escapees' work in the break room.
Steadman's money trail leads Veronica and Nick to a surprising discovery.
Michael must get the key to the infirmary and enlist the help of an old face, while Lincoln learns the identity of his kidnapper and another inmate learns of the escape.
Michael gets a visit from his wife, much to everyone's surprise. She brings him what appears to be a credit card, but is in fact something entirely different. Bellick does some research after seeing Michael's wife, whom he thinks looks familiar.
Michael learns that his watch has been stolen by a guard, and he must enlist the help of an inmate in order to get it back.
In the woods, Veronica, LJ and Nick are threatened by Quinn, who is determined to find out who else knows about the conspiracy.
Abruzzi's demotion in the prison hierarchy puts the entire escape plan at risk. Michael finds himself in the unenviable position of trying to protect T-Bag's new "fish" and facing the threat of T-Bag exposing the plan to the guards. The inmates dig themselves into a hole.
C-Note gets into a tricky situation when a robber holds up the diner he is in.
Michael, Lincoln and Kellerman get closer to revealing the conspiracy with the help of Sara.
Mahone recruits Bellick.
Veronica uncovers new information regarding Lincoln's case and decides she wants to work on the case full-time. When no one wants to help her, an attorney named Nick Savrinn offers his assistance and the two of them visit Lincoln.
Michael's new cellmate, Haywire, causes problems with the escape plans.
Michael and Sara request Henry Pope's help in retrieving the information that could possibly exonerate Lincoln.
Mahone pins down an escapee.
Sucre discovers a new threat while hitchhiking to reunite with Maricruz.
T-Bag brings the Hollander family to his home.
Flashbacks shed light on the past actions that led to the incarceration of Lincoln, Sucre, T-Bag and C-Note. The basis of Michael's ingenious break-out plan is revealed. Dr. Tancredi recalls how she ended up in Fox River State Penitentiary.
Lincoln works to retrieve the final card, which is being held by the General.
Michael and Self are forced to work with Gretchen. Meanwhile, Roland continues to be berated for losing the transcribing device in Las Vegas.
As the escape is in progress, Warden Pope and Captain Bellick begin a search to detain the escapees. Michael and company struggle to reach the airfield as the police is hot on their heels. Veronica discovers a major piece of evidence that could prove Lincoln's innocence. The Vice President is worried about losing her authority.moreless
When Michael reveals his escape plan to Sucre, Sucre chooses to be no part of it, and requests a cell transfer. Michael gets a new cellmate called Haywire.
Sara sacrifices herself for the safety of Michael so the brothers can get on with their final plan to attain freedom, but their plan gets 'shipwrecked'. Meanwhile, Bellick blackmails Sucre to partner up as T-Bag's streak of murder continues to the south of the border.
Michael risks his life by breaking into the Company headquarters along with the others.
Gretchen tries to get the last card with a meeting with the general.
Trishanne's days may be numbered.
The General works to regain Scylla.
T-Bag gets a new partner.
Michael and Lincoln have an important meeting.
The entire operation may be in jeopardy when Mahone gets into trouble with the law.
Gretchen's sister receives a surprise visitor.
The Company may be onto Self.
T-Bag continues to raise suspicions at Gate.
Familiar faces turn up as Michael tries to take down the Company.
Michael recieves medical attention.
Charles Westmoreland helps uncover the real secrets of Scylla.
Lincoln and Sucre do everything in their power to retrieve Scylla before it's gone forever.
Michael and Sara's newfound happiness is short-lived as Sara soon finds herself in prison, and Michael must get her out before a vengeful Krantz has her killed. Michael orchestrates his final prison break to free the vulnerable Sara.
Lincoln and his team travel to Miami looking for Scylla.
Michael learns some shocking secrets about his past while Sara searches for him.