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A pair of newlyweds from Boston joins the cattle drive after their wagon is washed away in a flash flood.
Jeannie watches from a distance as John Taggert kills her father Henry and leaves. An ex-con comes and takes Henry's clothes and catches Jeannie. He passes himself off as Henry and his little girl, Carie who doesn't speak.
Anton Zwahlen is burying his wife Freida. He asks to travel with the herd for a couple of days. He offers to clean and oil everyone's guns and instead sabotages them by filing down all the firing pins. Part of a plan by Anton's relatives to rustle the cattle.
A series of murders occur after four men join the cattle drive. The murders all have one thing in common - a steer appears after each death with the word "murder" branded on it.
Hey Soos's mother Rosa is branded a witch, and blamed for the lack of rain and an eclipse.
Wishbone has grown tired of all the jokes about his cooking. He leaves the cattle drive for romance and to start a restaurant.
A man called Pagan talks the drovers into visiting a nearby trading post for liquor. When they return, the herd is gone.
When a horse stolen from the drovers is found next to the body of Gypsy prince, the Gypsies accuse the drovers of murder.
Pete Nolan attempts to take an astronomer's wife back home to an observatory in the middle of nowhere. When they arrive they are met by an Indian woman and a man who claims he is the astronomer.
The drovers try to keep as much distance as possible between the herd and a wagon load of nitroglycerin.
After horse thieves hit the herd, the drive is at a standstill while Pete Nolan scouts for replacements.
An Easterner and his daughter are heading West when they have an accident. Pete Nolan and some friends help them out and they go on. Later, the girl mysteriously disappears.
A posse gives up looking for two outlaws, Vance and his partner. They come upon the body of a lawyer ambushed by Indians. Vance decides to pose as Jonathan Williams, attorney at law.
Favor clashes with his old enemy Jed Carst, a crude, illiterate man obsessed with capturing a wild stallion.
The drovers hold a mock funeral for Wishbone's wounded twin brother to deceive his Indian pursuers.
A guerrilla leader, a hotheaded marshal and an artist are key figures in this tale of misunderstandings and murder.
Favor goes on trial for murder while the wranglers search for the real culprits---an outlaw band on the lam after robbing a stagecoach.