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When a horse stolen from the drovers is found next to the body of Gypsy prince, the Gypsies accuse the drovers of murder.
Pete Nolan attempts to take an astronomer's wife back home to an observatory in the middle of nowhere. When they arrive they are met by an Indian woman and a man who claims he is the astronomer.
The drovers try to keep as much distance as possible between the herd and a wagon load of nitroglycerin.
After horse thieves hit the herd, the drive is at a standstill while Pete Nolan scouts for replacements.
An Easterner and his daughter are heading West when they have an accident. Pete Nolan and some friends help them out and they go on. Later, the girl mysteriously disappears.
A posse gives up looking for two outlaws, Vance and his partner. They come upon the body of a lawyer ambushed by Indians. Vance decides to pose as Jonathan Williams, attorney at law.
Favor clashes with his old enemy Jed Carst, a crude, illiterate man obsessed with capturing a wild stallion.
The drovers hold a mock funeral for Wishbone's wounded twin brother to deceive his Indian pursuers.
A guerrilla leader, a hotheaded marshal and an artist are key figures in this tale of misunderstandings and murder.
Favor goes on trial for murder while the wranglers search for the real culprits---an outlaw band on the lam after robbing a stagecoach.