Tina Fey: Scientists have identified an enzyme in onions that makes people tear up, which is the first step in creating genetically modified onions that don't make people cry. Hey, guys! AIDS! There are still people who have AIDS! Put the onion thing on the back burner and cure AIDS!
Tina Fey: Pamela Anderson and Kid Rock will reportedly get married next month at the MGM Grand in Las Vegas. The couple is registered at the Center for Disease Control.
Tim Russert: (to Senator McCain about President Bush) What if he forgets to run?
Sketches not shown in 60 minute version: "Gillian Woodward," "Top O The Morning," the last "The Ambigously Gay Duo," "My Big Thick Novel," and The White Stripes' performance of "We're Going To Be Friends."
John McCain is the first (and so far only) active U.S. Senator to host SNL.
This is the first episode featuring the sketch "Top O' The Morning".
This episode marks the last time Jimmy Fallon plays Randy Goldman in "Wake Up Wakefield".
Dean Edwards does not appear in this episode.
This episode was pre-empted in many areas, including Washington D.C., due to a sniper shooting that occurred earlier in the night.
Nelly and Kelly Rowland were originally scheduled to be musical guest for this episode. They will appear later in November.