While Charlie is still in his coma, the doctors try one last ditch attempt to wake him. A female jockey has a tough surgery performed on her by Joel.
A sick airline passenger is taken to the hospital. As Alex performs emergency surgery on the passenger, she believes the patient may be infected with a deadly and contagious virus.
Fear and doubt strike Joel in the OR, so Kinney takes him on a therapeutic trip to where she is originally from, then they try to rescue a woman who's pinned under a truck. Elsewhere, Charlie connects with a deceased therapist; and Alex cares for a fitness buff with a rare condition.
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Charlie is removed from the ventilator. It is discovered that a patient who arrives for a routine follow-up could hold the key to understanding Charlie's condition.
Dawn and Alex bicker over who will make decisions for Charlie. Charlie meets with a prisoner that has died in the spirit world.
Alex is performing a routine surgery when it takes a turn for the worse after the patient falls into a coma. Charlie connects with the patient and Alex gets personal with a case.
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When a hypnotist is called into the hospital to help with a patient who can't remember his identity, the man uses his psychic ability to connect Charlie and Alex.
A double hand reattachment gives Alex a chance to prove that she is still capable of being chief surgical resident. Maggie thinks a homeless man received the wrong diagnosis.
Alex must treat a patient who already has had multiple surgeries.
Alex treats a boy with mysterious symptoms and Joel and Maggie must help a patient despite his religious beliefs.
When Charlie Harris, Hope Zion Hospital's chief of surgery, falls into a coma, he ends up wandering the hospital in spirit form.
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