Professor Pericles' left eye keeps switching between green and orange throughout the episode.
Another one of the hypnotized girls is Suzie Chan, from The Amazing Chan and the Chan Clan franchise.
This is the first episode where we actually see a box of Scooby Snacks.
Aphrodite's face resembles the face of the victims of Batman's enemy The Joker after being exposed to his Smylex toxin.
If you pay attention, one of the girls that gets hypnotized by Aphrodite is Pebbles Flintstone, from The Flintstones franchise.
When Mayor Jones and Sheriff Stone warn everyone that Mystery Inc. is not under the influence of Aphrodite, in the next scene, you see a goth girl wearing her hair in pigtails. This girl resembles Abigail "Abby" Sciuto, played by Pauley Perrette in the CBS series NCIS.
Stephen King's Carrie
Someone getting a terrible revenge for supposedly being chosen prom queen and then humiliated by her peers is an obvious allusion and reference to Steven King's book Carrie, as well as its 1976 movie adaptation, starring Sissy Spacek, Amy Irving, John Travolta and Nancy Allen.
The Body Snatchers
The episode parodies the book The Body Snatchers, written by Jack Finney, which spawned various movie adaptations over the years.