John Dorian or "J.D.", is a boyishly handsome, likeable guy who would be confident if he only realised his assets. Four years of medical school have prepared J.D. for his first day as an intern at Sacred Heart Hospital — but he has his doubts. As J.D. is thrown into the chaotic world of hospital life, we not only get to see the quirky characters that he encounters, but also hear the humorous commentary of thoughts streaming through J.D.'s head.
The handsome and confident Chris Turk is J.D's buddy from college. As a new surgical intern, Turk struts around with a cocky demeanor that hides a terror that he only admits to J.D. The attractive Elliot Reid is a medical intern as well and J.D. quickly finds out her beauty is only surpassed by her hyper-competitive attitude.
Dr. Robert "Bob" Kelso, Chief of Medicine, 'the safety net' wants the interns to think they can count on him. On the other side of the personality spectrum is Dr. Percival "Perry" Cox, a steamroller of a man short on patience. Watching over the interns with a teasing but caring attitude, is nurse Carla Espinosa, a woman who is motherly and sexy at the same time — which appeals to Turk. The minor characters like Ted, Todd, Laverne and the Janitor are also there to offer their little jokes to this great pilot episode which couldnt have asked for more.