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Physics genius Quinn Mallory has been tooling around in his basement for months, trying to create an anti-gravity device. However, he has stumbled on to something much greater - something that appears to be a gateway! Curious as to what's on the other side, he invites his old friend Wade Wells and his physics teacher, Professor Maximillian Arturo, to venture into the gateway with him. While creating the gateway, however, Quinn uses too much power and the vortex snags a fourth passenger: Rembrandt Brown, a former pop star who just happened to be in the neighborhood. The vortex drops them in a world where a new Ice Age has begun, a world where they must somehow survive until Quinn's timer reaches zero.moreless
On a world where time moves at a slower rate, Quinn encounters his young double and tries to change a traumatic event in his life. Meanwhile, Arturo decides that it's time to grab life by the horns and takes the others on increasingly wild excursions.
The Sliders arrive on a world where clones are harvested for spare body parts. Quinn's double is blinded in a lab accident and when Quinn tries to help, he is mistaken for a clone. Meanwhile, the others inadvertently rescue the clone, which Colin tries to teach the importance of family and sacrifice.moreless
The sliders arrive on a world where electrically charged tornadoes have devastated the population. They soon discover a valley protected by lodestone, but the inhabitants of this valley are less than friendly to outsiders.
The sliders confront Dr. Geiger again, this time in a collapsing dimension full of innocent victims.
The timer continues to malfunction, giving the sliders rougher slides than usual. To fix it, the sliders need to get a hold of a special gem, even if it means stealing.
The Sliders are lost in the desert but come upon an archaeological dig. They soon find however, that the dig is unearthing a buried Los Angeles and that the locals consider Rembrandt a deity.
The Sliders arrive at a mental institution in the middle of an unusual riot. Rembrandt and Maggie escape capture but Diana and Mallory get left behind. While Mallory has managed to pose as a doctor, Diana is mistaken for a patient and undergoes the process of her brain being remapped.
The sliders narrowly escape from a world filled with parasitic creatures, but not before Maggie becomes infected. On the next world, the parasite searches for a host in order to reproduce.
The Sliders arrive on a world where millions play in highly realistic arcade simulations. Rembrandt and Mallory take part in separate simulations, until they discover Maggie and Diana have been forced to play characters in these simulations, where each "death" experienced is real.
A malfunctioning timer deposits the Sliders underwater in the Pacific Ocean. A merchant ship picks them up but is taking them out of their sliding radius and decreasing the likelihood of a safe slide. Their only chance is to join up with a pirate crew to get back to California.
The Sliders arrive on a world where combustion engines were outlawed by the government due to pollution. However a biker gang is fighting to keep their engines and Mallory falls for the gang's sexy leader.