Manson, 45, whose real name is Brian Warner, will play Ron Tully, "a white supremacist shot-caller whom Jax (Charlie Hunnam) uses to expand his power base" while in prison.
"Sons has been such a big part of my life, as well as my father's," Manson said in a statement. "I was determined to make him proud by being involved in what will probably be remembered as the most amazing piece of television cinema. After all, the very heart of SOA is about that relationship."
Added the singer: "Now all I need is a motorcycle."
This won't be Manson's first foray into acting. His previous television and film credits include Party Monster, Jawbreaker, and guest spots on Once Upon a Time, and Eastbound & Down.
Sons of Anarchy will return to FX this fall.