The camera zooms in to Kyle believing that Kyle has lice, but the camera moves away from Kyle and on to Clyde who has the lice.
Craig's hair is revealed to be black. It was black in "South Park is Gay" but changed to brown in "The Losing Edge". Here it reverts back.
During the scene where the Crab-like lice get Travis, he is seen walking. He couldn't be walking, even with help, because both of his knees were shot by the Vice-President.
This is the first episode that centers around Clyde.
Running Gags: Cartman accusing Kenny of having head lice because he's poor.
When the inspector checks Clyde's hair for lice, and Travis sees his eye, he has an iris, not just a pupil, like all characters in South Park have.
This is the third time Kenny's voice is heard unmuffled. He is heard during the sock bath yelling "No,NO!! Not the socks..."
This is the third time we see Craig uncapped where his hair was black in this episode. On the first time his hair was showed in "South Park Is Gay!", it was black but then in episode "The Losing Edge", his hair was brown.
Medic Woman: Now now, it's alright, we're going to call your parents and get you to your doctor.
Clyde: Please, you don't understand, the other kids are going to make fun of me forever.
Medic Woman: I'm sure your friends aren't that cruel.
Clyde: YES THEY ARE!
Cartman: Alright, the person who had head lice has to speak up right now so that we know to stay away from you.
Craig: Yeah come on. Were gonna find out sooner or later.
(No one owns up)
Cartman: Okay, whoever you are, you're now not only a lice head, you're a liar. You're only making this worse on yourself.
Kyle: You know what, i'll bet it was you.
Kyle: This is exactly what you would do if they found lice in your hair. Try to lead the charge against someone else to take the suspicion off of yourself.
Cartman: I don't think so Kyle. But you know what, this is exactly what you would do if you had head lice. Try to get everyone to blame me.
Stan: You guys stop it, this isn't getting us anywhere.
Cartman: That's exactly what you would do if you had headlice Stan.
Kyle: Yeah try to have everyone make peace so it doesn't seem like a big deal.
Cartman: And this is exactly what Kenny would do, stand there and say nothing.
Butters: Hey guys what would I do?
Butters: Boy, I sure hope they don't find lice in my hair.
Stan: What do you think happens if you do have it?
Cartman: They drag you outta here, put you in this big containment facility, where they stick this cold metal pipe up your ass with this clear jelly. And then they shock your balls.
Cartman: Kenny McCormick, you are charged of bringing head cooties into our school. How do you plead?
Kenny: (Muffled) Not guilty!
Cartman: Guilty! I thought so.
Kyle: It was him. It had to have been him.
Stan: Yeah. . . (pause) or you.
Vice President: Who put you in charge?
Travis: God did, when he killed my wife.
Cartman: This is ridiculous. All this just so they can send Kenny in a stupid head-lice home.
Kenny: (muffled) Dude, **** off!!
(at the doctor's office)
Clyde: This is SO embarassing.
Little Girl: I have an ear infection. What are you seeing the doctor for?
Clyde: I have...I have AIDS.
Cartman: (About the scalp inspection) This is completely unnecessary! Everyone knows that only poor people get lice. The only person that could spread it here would be Kenny.
Kenny:(Muffled) What!? f*ck you!
Mrs. Garrison: Apparently we have a little problem here at the school which we need to talk about.
Cartman: Ah, yes. You mean the "Jew" problem.(points at Kyle behind his hand) Good, good! I'm glad we're finally gonna do something about it.
Mrs. Garrison: No, I mean the problem of head lice.
In Latinamerica, this episode aired on October 14, 2007, on MTV.
This is the first episode to be centered around Kenny since "Best Friends Forever."
The day this episode originally aired, Al Gore appeared before Congress saying very similar things about the Earth and Global Warming as Travis says to the Lice President about Clyde's scalp and Scalpal Shampooing.
In this episode, we learn that Clyde's last name is now Harris. But, like Butter's dad, his name is subject to change. In the episode Quest For Ratings it is stated that Clyde's last name is Donovan.
When the Vice President is defeated at Clyde's hand (literally), Travis lies there bleeding and seriously injured....laughing. John McClane of the Die Hard series, also tends to laugh when his foe is defeated even if he is seriously injured.
The lice climb the hairs to avoid the green goo, just as the passengers climb the rails to avoid the sea in the 1997 film, Titanic. Similarly some also fail to hold on and fall in the same manner.
When one of the lice went to check on the green stuff which melted his hands, he is then standing in it and begins to melt away. This is a reference to Tommy Lee Jones 1997 film, Volcano where a rescue worker is carrying a man through the lava and throws the man to the other rescuers as he melts in the lava.
Superman: When Travis the lice father tells the Vice President about the world is changing and that they need to move to a new planet, the Vice President didn't believe. This is much like the Superman story where Superman's birth father warns the leaders of Krypton about the planet is about to explode and they didn't believe him until it was too late.
Full Metal Jacket:
When the kids grab socks and bars of soap, the initial thought is that they are going to beat Kenny with them a la Private Pyle in Stanley Kubrick's Full Metal Jacket (1987). This was a common act to see in the military during this era.
While at the doctor's office, Clyde's mom reads the magazine, Vague, which is an allusion to Vogue magazine.
Final Fantasy IX:
The way the lice saw the giant eye is similar how people saw it on the game of Final Fantasy.
The scene where the dying lice comes out and says "help me, help me" is a reference to a toxic waste scene in the 1987 film Robocop.
Planet of the Apes:
The Forbidden Zone on the boundaries of the louse civilization is a clear reference to the original 1968 film, Planet of the Apes where a similar Forbidden Zone exists.
Lord of the Rings: The Return of The King:
When the lice is saved in the end by the fly, it is similar to the scene in Lord Of The Rings: Return of the King (2003) when Frodo and Sam are saved by the Eagles from Mount Doom.
The scene where the boys are locked in the storeroom, Cartman's blood-jumping test is taken from the 1982 John Carpenter film, The Thing.
The title is an allusion to Ice Capades, a famous ice-skating entertainment show.