#10 – Dr. Doom – The Fantastic Four:
Joe O'Brien - Columnist for Rue Morgue: Describes Dr. Doom as the "Darth Vader of the comics"
Julian McMahon - Dr. Victor Von Doom: Discusses how he chose to play the character, and how he wanted to play it for the fans.
Nalo Hopkinson - Author/Playwright: Compares him to 'The Man in the Iron Mask', and how the anonymity of the character makes him more scary.
#9 – Dr. Evil – Austin Powers
Malene Arpe – Pop Culture Writer for The Toronto Star: Describes him as a parody of a number of sources, from Lorne Michaels in Saturday Night Live to James Bond, as well as many others, but a character which has now gotten tired and overdone.
Nalo Hopkinson - Author/Playwright: Calls him "big fun", a self-satirizing character.
#8 – Dr. Octopus – Spiderman
Avi Arad - Producer: Describes him as Spiderman's ultimate enemy, one who can do what Spiderman can, only better.
Alfred Molina - 'Dr. Otto Octavius/Doc Ock':Discusses how he wanted to make his character likable, to make his transformation more startling.
Laura Ziskin - Producer: Talks about how the character is a good man who's gotten carried away and had his dark side brought out.
#7 – Dr. Beverly Crusher – Star Trek: The Next Generation
Nalo Hopkinson - Author/Playwright: Compares her to "June Cleaver with a PhD.
Gates McFadden - 'Dr. Beverly Crusher': Hopes that her character might've encouraged people to go into medicine, as she feels that more healers are needed.
#6 – Dr. No – James Bond
Malene Arpe – Pop Culture Writer for The Toronto Star: Describes him as the "quintessential bad, mad man."
#5 – Voyager's Doctor – Star Trek: Voyager
Joe O'Brien - Columnist for Rue Morgue: Discusses how the Doctor was an amalgam of many personalities which results in a neurotic character, who just happens to be artificial.
Robert Picardo - 'The Doctor: Describes how his character was supposed to be a satire of US healthcare, whose goal is simply to get patients through the system as quickly as possible.
Nalo Hopkinson - Author/Playwright: Talks about how the Doctor uses his limitations to become more human.
#4 – Dr. Zaius – Planet of the Apes
Joe O'Brien - Columnist for Rue Morgue: Discusses how Zaius uses his knowledge to keep his people ignorant and easily controlled, contrary to most of the doctors in science fiction.
Malene Arpe – Pop Culture Writer for The Toronto Star: Describes him as an example of the modern faith-based science, who actually destroys information to keep people from questioning.
#3 – Dr. Baltar – Battlestar Galactica (2003)
James Callis - 'Dr. Gaius Baltar': Discusses how his character is in a very deep crisis, which affects not only himself but also everyone around him.
Malene Arpe – Pop Culture Writer for The Toronto Star: Describes him as a fantastic character, not just in the setting of the series, but also as a study of a total "bonkers, bad-ass crazy".
James Callis - 'Dr. Gaius Baltar': Theorizes that without his trysts with Number Six, Dr. Baltar would be much less interesting.
Malene Arpe – Pop Culture Writer for The Toronto Star: Calls him "an interesting crazy person with a fantastic sense of self-preservation."
#2 – Dr. McCoy – Star Trek: The Original Series:
Joe O'Brien - Columnist for Rue Morgue: Describes the character as the anchor of Star Trek, the guy who's not interested in the technological aspects of the situation.
Nalo Hopkinson - Author/Playwright: Discusses how he's "the country doctor" who comes to you.
Joe O'Brien - Columnist for Rue Morgue: Talks about why the 'triumvirate' of Trek worked so well, with Spock's logic and Kirk's boldness tempered by McCoy's humanity.
#1 – Doctor Who
Peter Davison - 'The Doctor (5th)': Theorizes that it was so successful because it wasn't formulaic and didn't conform to any preconceptions.
James Callis - 'Dr. Gaius Baltar': Discusses how his favorite sci-fi doctor is Doctor Who, and how when he was a kid, even the theme music of the show creeped him out.
Joe O'Brien - Columnist for Rue Morgue: Describes how this character is totally enigmatic, but the two things known about him – his title of Doctor and his use of a police box to travel – imply that he is about healing and a sense of justice.