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The Kingpin is furious at Spidey and sends the Shocker and later the Rhino out to finish him off with the aid of another new invention of Alistair Smythe. Meanwhile, Eddie Brock, as the symbiote creature Venom, is busy playing cat and mouse with Spider-Man, intruding on Peter's private life and making it clear he knows the web-slinger's secret identity. Peter soon realizes that the pumped-up Eddie as Venom is stronger than he is. Worse than that: Spidey's spider-sense doesn't work around him!moreless
The Crime Lords, led by Silvermane, are holding The Kingpin accountable for his failure to eliminate Spider-Man. So six of the Wall-Crawler's greatest enemies are called together to do the job: Doctor Octopus, Mysterio, The Scorpion, The Rhino, The Shocker and The Chameleon. Unfortunately, Spidey's powers have been on the blink due to the changes in his blood chemistry.moreless
Spider-Man's progressing neogenic mutation is making him ill and he seeks the aid of a man known to help all mutants...Dr. Charles Xavier. In doing so he meets the X-Men but is disappointed to learn that Xavier does not 'cure' mutancy, only helps those born that way to accept and control their abilities. In the process of this endeavor, he crosses paths with Herbert Landon, who plans on destroying mutants everywhere. Will he be able to stop this hideous plan with the help of the X-Men?moreless
Peter is framed for a crime he didn't commit and it's up to blind lawyer Matt Murdock to prove his innocence, who is also known as the Man without Fear, Daredevil.
Wolverine joins Spider-man in the search for Beast. Landon is about to make Beast the first test subject of his new formula, one that could destroy every mutant. Will Wolverine and Spider-Man make it in time to save their blue friend, or will a newly mutated Landon destroy them all?
Harry's father Norman Osborn disappears after an explosion at his chemical plant. Spidey's search for his friend's father one way or another meets with complications. Namely an airborne fiend who calls himself the Green Goblin!
Spider-Man must battle his own teacher when New York State University science professor Dr. Curt Conners is transformed into a monstrous lizard creature as a side effect of an experiment that allows lost limbs to grow back.
Adrian Toomes wants revenge when Norman Osborn attempts to take over his company, Toomes Aerodynamic. He becomes the Vulture and uses his youth stealing talons to help him gain the strength to take out Norman. He is even able to use Debra and Dr. Connors, who work on Neogenics at his own lab due to the Toomes grant, to supply him with youth. Will Spider-Man be able to stop this bird of prey before he turns Norman into bird feed?moreless
Mary Jane is being stalked by her former boyfriend, Morrie Bench, who's undergone an accidental metamorphosis and become Hydro-Man. Sweeping Mary Jane off her feet in a wave of water he insists she will love him. Spider-Man is nearly beaten by the semi-liquid culprit, but with a little help from Mary Jane, can the two put an end to Hydro-Man?moreless
As Kingpin and Silvermane fight for control over the Tablet of Time, Silvermane finally wins out in the end. Using the tablet, he is able to be transformed into a young man. Spider-Man, Kinpin's Mega-Slayer, and Dr. Connors, now transformed into the Lizard, attempt to stop him, Tombstone, and Alisa. Will Silvermane triumph, or will his greatest wish be his own downfall?moreless
Dr. Mariah Crawford develops a cure for Spider-man's mutation, but she doesn't want to use an untested serum. Spider-man takes the serum and runs his own test which is stolen by Michael Morbius who runs some test of his own. When his tests go wrong, will Spider-Man actually have to fight a former friend?moreless
Ex-employee of Stark Industries, Dr. Jonathan Ohn, invents a portable interdimensional technology that accidentally makes him the living embodiment of a portal. Calling himself the Spot, he tries to steal money to fund his research. But his unstable invention has created a vortex that threatens to engulf New York. How can Spider-Man fight that?moreless
Robbie has set Peter up with a job interview with a researcher by the name of Dr. Mariah Crawford. However, when he gets to her lab, he finds her under attack by a monstrous man who deems himself Kraven the Hunter. Threatening Spider-Man by kidnapping Robbie, can Spider-Man rescue Robbie while fighting this beast of a man?moreless