Continuing directly from where the last episode left off, Spidey has to face the Insidious Six in order to save his Aunt. Only problem is, he can lose his powers at any moment because of his disease. The animated fight scenes are spectacular, as Spidey is more than overpowered by his enemies. They capture him, and are ready to unmask him.
The build up is nerve wracking, and the moment Doc Ock removes Spidey's mask to uncover Peter Parker was one of the most intense secenes this show offered so far.
Fortunately for Spidey, Doc Ock believes Peter just put on a Spider-man costume to come and save his aunt, and that he isn't the real Spidey. This saves Peter, but only for the moment, as the Insidious Six take him hostage, and force him to take them to real Spider-man. Peter accepts, seeing that there is no other way to save his aunt. A nice touch was the way the relationship between Peter and Doc Ock was expanded. Since it was introduced back in the first season, it developed and offered us some more exciting scenes in this episode.
Peter manages to escape from the Insidious Six, by faking his rescue by Spidey himself. Spidey battles the Six once again and, even if he doesn't win the battle, he comes close to it. He manages to escape this time, when the Kingpin calls his Insidious Six back to their headquarters for another job: kidnapping Silvermane, another crime boss and his rival.
Spidey comes to save Silvermane, and defeats the Insidious Six one by one, by using his mind. A rather simple task, seeing that the Rhino was one of the Six, and his intelligence was a little low. By tricking various of his enemies he is actually the Chameleon disguised as Spider-man, Spidey manages to turn the Six against each other, letting him escape together with Silvermane (who he doesn't know who he is, but will learn later on during the series, in another story arc).
The ending was incredibly well done, and one of the most exciting ones the show ever had (possibly second only to Venom's first appearance on the series): Spidey, now cured and happy (or so he thinks), is talking to Doctor Connors about his test results, believing they won't create him anymore problems. But what Connors tells him shocks him (as well as us, the viewers): he is turning into something that is not human.
Overall, a really good episode with a superb ending. And this is only the beginning of Spidey's Neogenic Nightmare.