Goof: When Archer and Sato are rescued from the planet, their uniforms are naturally torn and dirty, yet when they are brought to the bridge by Phlox, their uniforms are now clean and untorn, and their hair looks normal. The time frame of this sequence of events didn't allow for them to get treatment, get changed and get their haircuts.
Nitpick: T'Pol tells Enterprise that they are being mutated, and to send a security team. However, at this point there is no apparent security risk, and it furthermore seems highly illogical to risk further infection by sending more crewman to the surface. It would seem to be a better option to request to be beamed up to the ship, or at least to request that a medical team be sent down.
Nitpick: Considering that there is an alien species that takes it upon themselves to "quarantine" and eliminate anyone infected with the virus, and keep a close enough eye on the planet to do so regularly, it seems highly unlikely that they would neither place a warning beacon in orbit, nor personally warn the Xindi ship or Enterprise.
Archer : Captain's starlog, supplemental. We've given Phlox's serum to the captain of the containment vessel. With any luck, they'll be able to use it to prevent future outbreaks. As for Malcolm, Hoshi, and me, it may be a few days before we feel fully human again.
Archer: We came out here to stop the Xindi from destroying humanity. I'll be damned if I have a hand in destroying another race in the process.
Reed: What do you suggest I eat?
Phlox: You're welcome to some of the moth larvae I feed my pyrithian bat.
The director of this episode, LeVar Burton, previously played Lieutenant Commander Geordi LaForge on Star Trek: The Next Generation.
This episode marks the change in the series' official title, as seen in the opening credits, from Enterprise to Star Trek: Enterprise.
Jerry Fleck, a first assistant director for several Enterprise episodes, including this one, died shortly after filming. As such, this episode is dedicated to his memory.