Trivia: Hoshi was discharged from Starfleet before serving on Enterprise.
Trivia: Other than the Klingons the Mayweather Alien mentions, they have also observed the Cardassians.
Trivia: The advanced, non-corporeal aliens identify themselves as Organians, the same race observing the conflict between the Federation and Klingons in The Original Series episode "Errand of Mercy". Continuity is preserved by having the crew's memories altered to forget being in contact with them.
Trivia: Hoshi reveals she has a black belt in Aikido.
Trivia: This episode marks the first mention of Cardassians in Enterprise.
Trivia: After Hoshi hacks the security system and gets out of the decon chamber, she runs to a bulkhead and shouts in Russian: "Mnje nuzhno skazat' Doh svihdahnija!", which means "I need to say 'Goodbye'". Her accent is a little weak, though.
Archer : To the Organians after they refuse to help "You miss what it mean to be human. You need to do more than observe."
Lt. Reed/Organian: You're really starting to get a feel for the game.
Ensign Mayweather/Organian: 32 pieces, 64 squares - it's not as if it's difficult. Total number of possible outcomes is limited.
Lt. Reed/Organian: Ten to the 123rd power.
Ensign Mayweather/Organian: That's what I mean. Chess is so predictable. I'm surprised anyone bothers to play it.
Trip: The next time I ask to go on a landing party, talk me out of it, okay?
Archer: You're usually too stubborn to be talked out of anything - but I'll do my best.
Trip: You're a genius. The way you can pick up an alien language you've never heard before and start spouting it back to them. I got to tell you, I've always been jealous you can do that.
Hoshi: I wish I could fix warp engines with duct tape and a pocketknife.
Trip: It's a bit more complicated than that... sometimes.
(The Organians are getting ready to leave Enterprise and are talking to each other through Malcolm and Travis)
Malcolm: You realize the consequences of what we've done. We will never be able to observe another species encounter this virus.
Travis: Good. I'm looking forward to making my first report. After 10,000 year's the rules need to change.
Malcolm: These humans have not been a good influence on you. I would not encourage further encounters.
Travis: I don't think we can avoid them. I'm going to recommend that we start preparations for an Official First Contact mission.
Malcolm: Indeed. At the rate they're progressing, that'd barely give us 5,000 years to prepare. Then we'd better get started.
(Hoshi is trying to unlock the door to the decontamination chamber)
Trip: You can't break the lock-out code.
Hoshi: Math is just another language.
(doors open and an alarm sounds)
(talking with Hoshi, who is in decontamination chamber with Trip and coughing)
Archer: Hoshi, what is it?
Hoshi: Before Commander Tucker passed out, he started coughing.
Phlox: Are you feeling any other symptoms?
(Hoshi runs to bathroom and starts retching)
Trip: I'm gonna guess that's a yes
The first run episode of this episode had a 1.6/3 rating share.
Trip: Have you ever heard of the movie The Andromeda Strain?
Trip and Hoshi have contracted an incurable alien virus. The Andromeda Strain is a 1971 movie about an incurable alien virus that comes to Earth.