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Trivia: At the end of the episode, T'Pol estimates it will take 200 years before the message is received by the Borg, and Archer replies: "So, in the 24st century?" The 24st century is indeed when the Borg start attacking Earth and try to invade, a time in which the other Star Trek series are situated.
Trivia: Amongst the debris of the Borg Sphere, there is the Enterprise-E's saucer section model (from Star Trek: First Contact).
Trivia: "Regeneration" introduces a potential predestination paradox. T'Pol reveals at the end of the episode that the freighter sent a subspace message to the Delta Quadrant; she theorizes that it will take at least 200 years to arrive. Before the Borg's encounter with the Enterprise-D in The Next Generation episode "Q Who?", they attacked and assimilated several Federation and Romulan colonies in "The Neutral Zone". That probe may have been the result of the signal this group of Borg sent. Those events lead to the Borg attack on Earth in Star Trek: First Contact, which sends the sphere into the past that the science team finds.
Mission Date: March 1, 2153
Trivia: One of the human scientists says that she is picking up a warp signature, and traces it to a small round device inside a piece of debris. Although the scientists conclude that it is too small to be an engine, it is, in fact, a transwarp coil.
Trivia: One of the human scientists says the the hull fragments from the alien vessel all had the identical curvature, and she conjectures that it might have been a perfect sphere. This is exactly correct, as in Star Trek: First Contact, it is a Borg Sphere that emerges from the destroyed Cube and travels back in time to assimilate Earth. It is this Sphere that is then destroyed by the Enterprise-E.
The scanner used by one of the human scientists is identical to Crewman Daniels' futuristic device seen in the season one's "Cold Front".
Goof: While testing the modified phase weapons, Lt. Reed mentioned an input value in megajoules. He then ordered the "power" to be raised, but still quoted a value in megajoules. Joules are not a measure of power, but a measure of energy. Power is the rate of dissipation of energy and is measured in watts or, at the power levels that Reed was providing, megawatts.
Trivia: Ruby, a barmaid who both Malcolm and Trip were in love with ("Shuttlepod One"), appears in this episode. She is portrayed by Brigid Brannagh.
Trivia: This episode reveals how/when Archer and Trip met.
Trivia: The episode reveals the meaning of Commander Tucker's nickname "Trip". His father and grandfather are both named Charles Tucker, thus he is Charles Tucker III (the third, or Triple, shortened to "Trip").
It is highly unlikely that a cure is found for T'Pol's Pon Farr; in the 24th century ("Blood Fever"; Voyager series) the Doctor has all medical knowledge of centuries and does not know of a cure, nor find any. Arguably, T'Pol underwent Ponn Farr because of a virus, but in the Voyager episode even B'Elanna could not be cured when she entered Ponn Farr as a Klingon/Human hybrid due to an accident.
T'Pol says that because of the Pon-Farr she must mate with a male, Vulcan or otherwise. Previously, Vulcan males going through the Pon-Farr have explicitly required a Vulcan female.
Though mentioned many times, this episode marks the first appearance of the Tellarites in a speaking role since The Original Series.
Mission Date: March 21, 2153
Nitpick: In season one's "Sleeping Dogs", T'Pol states that Klingons don't use escape pods. Nevertheless, in this episode, Archer escapes from the Klingon transport using an escape pod. However, although Klingons would never use escape pods if their ship is destroyed in battle, it is possible that Klingon ships nonetheless have them in case the vessel is destroyed by other means.
Mission Date: April 24, 2153
This is the final episode to feature the mysterious "Future Guy". His identity, or his ultimate plans for the Suliban are never revealed.
Enterprise retains a complement of spatial torpedoes after her torpedo systems are refitted.