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Nitpick: The Hippocampus, which is responsible for holding short-term memories, is only capable of holding these memories for a few minutes. As such, if Archer is no longer capable of creating new long-term memories, he should only be able to remember things for a few minutes, not a few hours.
It has been three months since Enterprise entered The Expanse.
Nipick: Trip asks Archer for permission to take apart the Xindi-Reptillian weapon to study it. However, in "Rajiin", Archer already said specifically that he wanted it taken apart to be studied.
Gralik mentioned that there was a sixth Xindi species, the Avians, that had become extinct.
Goof: Inside the Xindi lab Reed pulls the fourth Kemocite canister from the crate and scans it. However, in the next shot as the Xindi are returning, the third canister is missing rather than the fourth.
Trivia: When Enterprise arrives at Tarquin's planet, the view from space shows that one of the continent's looks similar to that of the African continent on Earth.
Nitpick: Considering his lonliness in isolation, and Hoshi's refusal to stay, it seems odd that Tarquin wouldn't request to come aboard Enterprise.
Goof: When the power goes off on Enterprise, the bridge monitors merely project a full screen of black, but do not actually go off.
Goof: When Archer and Sato are rescued from the planet, their uniforms are naturally torn and dirty, yet when they are brought to the bridge by Phlox, their uniforms are now clean and untorn, and their hair looks normal. The time frame of this sequence of events didn't allow for them to get treatment, get changed and get their haircuts.
Nitpick: T'Pol tells Enterprise that they are being mutated, and to send a security team. However, at this point there is no apparent security risk, and it furthermore seems highly illogical to risk further infection by sending more crewman to the surface. It would seem to be a better option to request to be beamed up to the ship, or at least to request that a medical team be sent down.
Nitpick: Considering that there is an alien species that takes it upon themselves to "quarantine" and eliminate anyone infected with the virus, and keep a close enough eye on the planet to do so regularly, it seems highly unlikely that they would neither place a warning beacon in orbit, nor personally warn the Xindi ship or Enterprise.
This is the first episode in which an Enterprise crewmember dies (Crewman Fuller).
This episode introduces the "spheres", which will become an important part of the Xindi/Delphic Expanse story-arc.
Nitpick: The Osaarian tells Archer that his ship and another Osaarian vessel tried to leave the expanse the same way they entered, but that the barrier only allows ships in, and that the other ship was destroyed attempting to exit through it. However, in "The Expanse", Soval spoke of a report of a Klingon ship that had been witnessed leaving The Expanse.
Goof: At the beginning of the episode, when Phlox is looking at his animal cages, a wire can be clearly seen attached to one of them - presumably the means by which the cages are shaking.
Enterprise retains a complement of spatial torpedoes after her torpedo systems are refitted.
Mission Date: April 24, 2153
This is the final episode to feature the mysterious "Future Guy". His identity, or his ultimate plans for the Suliban are never revealed.