The Borg are not a race or a species, at best they are a culture and humans have been destroying cultures for a variety of reasons for a long time.
I think we can generally agree that destroying any culture like say that of some benign indigenous peoples for primarily economic or xenophobic reasons is very immoral/unethical.
Nazism, white supremacist, Jihadi, militaristic imperial Japan are all cultures or at least sub cultures -yet destroying these cultures is moral/ethical/good.
The dude who got down voted to hell is quite right about the ridiculous undertones in this episode.
Now I can't think of an enemy that Picard can't deal or negotiate (on some level) with . .it's BS and super annoying.
The implication of their behavior is that our intrepid heroes would actually try to negotiate and reason with a zombie apocalypse at the expense of millions; if not billions of lives -after all said zombies never asked to be zombies nor do they have control over their actions.
All of the good introspection does not belong in this episode and definitely not attached to the Borg, DS9 got it right with the Cardassians -an enemy that is quite different but with at least some common values/principles which one can use to 'humanize' their view of them.
If someone's sole purpose in life is to kill you at all cost, WTF do you think negotiating or empathizing with said person will accomplish?
This story has psudo depth, saying it has some profound message is like saying someone is intelligent solely because he has a English RP accent. . .the person may in fact be intelligent but you reveal yourself as a moron.