This is the first episode in which Dr. Stowe's embryo implantation is mentioned. It plays a significant role in many other episodes.
Nick's four sisters and specifically his sister Frankie who is a lesbian and is mentioned in later episodes are mentioned for the first time in this episode.
Lu calls Marc "Marco Antonio" when being stern in this episode.
Dakota Fanning and Chase MacKenzie Bebak have appeared together twice - first in this episode of Strong Medicine and then later in the movie I Am Sam.