I think aussiemovieguy is referring to the fact that everything seems to happen to Sam ( a lot more than Dean, anyway). If this was Dean without a soul, I highly doubt there would be as many complaints.
Just a few things I remember happening to Sam:
1. Sam was chosen to be a "demon child" by Azazel,
2. If I'm not mistaken Sam was the first to die of the Winchester Brothers. I could be wrong on this though, because I'm not sure if that one death of Dean counts, or whether it occurred first. But if Dean did die first (technically), I'll just go and say what I meant was Sam's death actually had more of an effect than Dean's death, probably since Dean was in-between life and death, but Sam was straight-out dead.
3. While it was at the expense of Dean, Sam did have to endure countless Dean deaths is what was it? "Mystery Spot?"
4. Sam seemed to be heavily picked on from Gabriel in the Changing Channels Episode,
5. Sam "sacrificed" himself to bring Lucifer back into the cage.
6. Sam has no soul.
There are probably others, but I always got the feeling that Sam was a bit more picked on than Dean (not to say that Dean hasn't been picked on, but like I said, Sam seems like the writers' punching bag).
However, since we leaned that Sam has a soul a few episodes ago I really can't see aussiemovieguy's point. I mean what do you mean "I am over the fact that something is wrong with Sam"? Because to me I don't understand that complaint because we know what's wrong with Sam, he has no soul, now were just seeing what happens when someone without a soul interacts with the world. However the complaint makes it seem like we don't know what's wrong with Sam. Except we do so the complaint just doesn't make much sense to me. I mean obviously we can't have Sam getting his soul back after like one episode, because how many chances are we going to see someone without a soul interact with the world on Supernatural?
But then again Dean was the first one to go to hell so at least he did something first.