John argues that if Sam had shot the Yellow-Eyed Demon, Dean wouldn't have been in a coma, and Sam seemingly agrees. However, the Yellow-Eyed Demon wasn't the one who rammed the Impala, but rather one of his minions. Sam knew that, and would have told John. If the Yellow-Eyed Demon was dead, the truck driver demon would have attacked the Winchesters anyway. Given that, John's assertion is false, but Sam doesn't point that out.
When Sam was reading John's journal in Dean's room, the lights are off.
When Sam and John are fighting, they yell at each other and make a lot of noise, but no doctor or nurse come in to tell them to keep their voices down, since they're in a hospital and the door is open.
At the end of "Devil's Trap" there is blood on Dean's cheek and on his chin. In the same scene at the beginning of this episode there is blood pouring from his forehead and no blood on his chin.
If there was an entry in John's journal about Reapers, the boys should have found it in "Faith" and already have known about it.
Trivia: The date on the monitor when the doctors are resuscitating Dean is August 12th, 2006.
When Dean is comatose, he is connected to several machines. However, when he wakes up, the doctors seem to have taken them all off. Even while John was in the hospital for observation he was on a heart monitor, but Dean doesn't even have this. The monitor for Dean should still be in place, even hours after he woke up.
When Dean first meets Tessa on the steps, a man in a striped robe is being helped down the steps by a nurse and they head off to the left out of the shot. A minute later the same guy is seen walking back into the shot heading to the right this time walking without any help.
When the doctors are doing CPR on John they are actually pressing on the right side and near the bottom of the ribs, CPR is done at the xyphoid process, at the lower middle of the chest.
When doctors are trying to revive John, near the end the screen says, "Sensor off patient, check connection at patient. "
When the doctors are shocking Dean's heart, the right paddle of the defibrillator is in the wrong spot. It's meant to be further to the right.
Trivia: John Winchester dies at 10:41 a.m August 13th, 2006.
(Tessa and Dean see Tessa hooked up to life support)
Tessa: I don't understand. I just came in for an appendectomy.
Dean: I hate to bear bad news, but I think there were some complications.
Dean: Come on, Dad, you gotta help me. I gotta get better, I gotta get back in there. You haven't called a soul for help. You haven't even tried. Aren't you gonna do anything? Aren't you even gonna say anything? I've done everything you've ever asked me. Everything. I've given everything I've ever had. Are you just gonna sit there and you gonna watch me die? What the hell kind of father are you?
(Sam and Bobby regard the wrecked Impala)
Sam: Oh man, Dean is gonna be pissed.
Bobby: Look, Sam... this just ain't worth a tow. I say we empty the trunk, sell the rest for scrap.
Sam: No. Dean'd kill me if we did that. When he gets better, he's gonna want to fix this.
Bobby: There's nothing to fix. The frame's a pretzel, the engine's ruined. There's barely any parts worth salvaging.
Sam: Listen to me, Bobby. If there's only one working part, that's enough. We're not just gonna give up on...
Bobby: Okay. You got it.
Tessa: Well, like you said, there's always a choice. I can't make you come with me, but you're not getting back in your body and that's just facts. So yes, you can stay, you'll stay here for years disembodied, scared, and over the decades it'll probably drive you mad. Maybe you'll even get violent.
Dean: What are you saying?
Tessa: Dean, how do you think angry spirits are born? They can't let go, they can't move on, and you're about to become one. The very thing you hunt.
Sam: (with ouija board) Dean? Dean, are you here?
Dean: (as spirit) God, I feel like I'm at a slumber party.
Tessa: It's time to put the past behind you.
Dean: And go where?
Tessa: Sorry. I can't give away the big punchline...
John: Here. Give them my insurance.
(hands insurance card to Sam)
Sam: "Elroy McGillicuddy?"
John: And his two loving sons.
Tessa: What's happening to me? Am I dead?
Dean: That sorta depends.
John: You know when ... when you were a kid, I'd come home from a hunt, and after what I'd seen I'd be... I'd be wrecked. And you, you'd come up to me and you put your hand on my shoulder, you'd look me in the eye and... you'd say "it's okay, Dad." Dean... I'm sorry.
John: You shouldn't have had to say that to me. I should have been saying that to you. You know, I put... I put too much on your shoulders, I made you grow up too fast. You took care of Sammy, you took care of me. You did that, and you didn't complain, not once. I just want you to know... that I am so proud of you.
John: Where's the Colt?
Sam: Your son is dying, and you're worried about the Colt?
Sam: So what, are we supposed to do, just sit here with our thumbs up our ass?
Dean: Come on, Sam. Go find some hoodoo priest to lay some mojo on me. I'll be fine.
Sam: Look, since the doctors won't do anything, then we'll have to. That's all. I don't know, I'll find some hoodoo priest and lay some mojo on him.
Dean: Screw you, Doc, I'm waking up!
Tessa: It's an honorable death. A warrior's death.
Dean: I think I'll pass on the 72 virgins, thanks. I'm not that into prude chicks anyway.
Tessa: (deadpan) That's funny. You're very cute.
Dean: Have you heard of an out-of-body experience?
Tessa: What are you, some New Agey guy?
Dean: You see me messing with crystals or listening to Yanni?
Tessa, the Grim Reaper featured in "In My Time of Dying," was inspired by Death, a character in Neil Gaiman's Sandman comics.
Germany: December 10, 2007 on Premiere Serie
Denmark: November 5, 2006 on TV3
Portugal: March 12, 2007 on AXN
France: September 17, 2007 on TF6
Italy: June 24, 2008 on Rai2
The Netherlands: December 7, 2008 on Net 5
New Zealand: January 23, 2009 on TV2
In the closed captioning for this episode, there are a number of instances where a "Dr. Bender" is being paged, referencing the previous episode from the first season, "The Benders."
In addition to the new fiery opening sequence, the "A" in "Supernatural" shown during the title sequence is a pentagram, which has magical associations, and when inverted, is a demonic symbol.
At the beginning of the episode, "Bad Moon Rising" is playing in the background. This song was also playing in the final scene of the season finale "Devil's Trap."
When the little girl goes into Code Blue, the announcement is made on the loudspeaker, "Paging Dr. Kripke." Kripke is the last name of the creator of Supernatural.
Music: Stranglehold by Ted Nugent and Bad Moon Rising by Creedence Clearwater Revival.
This is the first episode to air after Supernatural made the switch to the newly-formed CW network. The show had run on the WB for its first season.
Dean: I think I'll pass on the 72 virgins, thanks.
According to a popular but controversial interpretation of the Koran, people in paradise are given virgins as a reward. The number 72 is specified in one of the Hadith, a collection of Islamic prophet Muhammad's actions and statements.
Dean: You see me messing with crystals or listening to Yanni?
Yanni is a Greek keyboardist and composer of contemporary instrumental music. He had been nominated for a Grammy Award twice. Yanni was the first major Western artist to ever perform and record at the great architectural achievements of the Taj Mahal in India and The Forbidden City in China.
Dean: Come on, you're the psychic. Give me some ghost whispering or something.
Referring to the TV show Ghost Whisperer, which stars Jennifer Love Hewitt as a young woman with the ability to communicate with earthbound spirits.
Dean: Dude, I full-on Swayze'd that mother!
Referencing the 1990 film, Ghost, starring Patrick Swayze as a ghost, who is able to move objects when angry.
This is the same as the Led Zeppelin's song "In My Time of Dying," from the album Physical Graffiti.