Trivia: In John's motel room, among various maps and handwritten notes, there are also three books: Igloo Killinek by Kenneth C. Butler; Air Force One Is Haunted by Robert J. Serling and, surprisingly enough, Secrets by Danielle Steel.
Talking about the Colt in the previous episode, "Dead Man's Blood" John said that thirteen bullets were created, and half a dozen were used. Onscreen images showed thirteen bullets then seven bullets. Now John says only four bullets are left. One was used on the vampire last episode, so where are the other two?
The road sign at the Salvation town limits has what appears to be a Bible verse on it: "Are you ready for Judgement Day? - JW 2:27".
However, "JW" does not refer to any book of the Bible, so this verse does not exist.
Trivia: In freeze-frame, you can see that the dagger the priest throws at Meg has "God's Eye" inscribed on it, along with other mystic markings.
Trivia: At 04:34, there's a note John posted on the wall. It says "sleep easy motel" with a picture of the demon (?) holding an orb of some sort, the gun (with the words 'the one only one' and 'SAM'), and there's a phone number - 555-0918 with the name Gerry.
John yells at Dean for not telling him about Sam's visions. In the episode "Home," Missouri says "that boy has such powerful abilities, why he couldn't sense his own father, I have no idea". When she said that John was sitting right there. He acted like he didn't know what was happening but he knew 11 episodes ago.
John: I just want to buy a few hours, that's all.
Sam: You mean for Dean and me. You want us to stay here and kill this demon by ourselves.
John: No, Sam, I want to stop losing people we love. I want you to go to school, I want Dean to have a home. I want Mary alive. It's just... I just want this to be over.
Sam: The last time I saw you, you fell out of a window.
Meg: Yeah, thanks to you. That really hurt my feelings, by the way.
Sam: Just your feelings? That was a seven-story drop.
Meg: Let me speak to your dad.
Sam: My dad? I don't know where my dad is.
Meg: It's time for the grown-ups to talk, Sam. Let me speak to him now!
Dean: Sam, I wanna waste it. I do, okay? But it's not worth dying over!
Dean: I mean it! If hunting this demon means you getting yourself killed, then I hope we never find the damn thing!
Meg: Well, I've lied... a lot. I've stolen. I've lusted. And the other day I met this man – a nice guy, you know? And we had a really good chat...sort of like this. Then I slit his throat and ripped his heart out through his chest. (her eyes turn black) Does that make me a bad person?
Pastor Jim: I like to say, Salvation was created for sinners.
John: I'm going to kill you.
Meg: Oh, John, please – mind your blood pressure.
Sam: I wonder how Dad is doing.
Dean: I'd feel a lot better if we were there backing him up.
Sam: I'd feel a lot better if he were here backing us up.
Dean: You said yourself once, that no matter what we do, they're gone and they're never coming back.
Sam: Don't you say that, not you, not after all this, don't you say that!
Dean: Sam, look. The three of us, that's all we have. And it's all I have. Sometimes I feel like I'm barely holding it together, man. And without you or Dad...
Sam: Maybe we could tell them there's a gas leak. Might get them out of the house for a few hours.
Dean: Yeah, and how many times has that actually worked for us?
Sam: Yeah. Could always tell them the truth.
Sam and Dean: Naaah.
Meg: You're dead, John. Your boys are dead.
John: I never used the gun, how could I know it wouldn't work?
Meg: I am so not in the mood for this, I've just been shot!
John: Well, then, I guess you're lucky the gun wasn't real.
Meg: That's funny, John. We're gonna strip the skin from your bones, but that was funny.
Sam: Dean, uh, I want to thank you.
Dean: For what?
Sam: For everything. You've always had my back, you know. Even when I couldn't count on anyone, I could always count on you. And, uh, I just wanted to let you know, just in case.
Dean: Whoa, whoa, whoa! You kiddin' me?
Dean: Don't say "just in case something happens to you," I don't wanna hear that freakin' speech, man. Nobody's dying tonight. Not us, not that family, nobody. Except that demon. That evil son of a bitch ain't gettin' any older than tonight, you understand me?
John: All right, something like this starts happening to your brother, you pick up the phone and you call me.
Dean: Call you? Are you kiddin' me? Dad, I called you from Lawrence. All right? Sam called you when I was dying. Gettin' you on the phone, I got a better chance of winning the lottery.
John: You're right. Although I'm not real crazy about this new tone of yours, you're right. I'm sorry.
Layla: Hi, is there anything I can do for you?
Dean: Oh God, yes.
Pastor Jim: I know what you are. You can't be here. This is hallowed ground!
Meg: Please, maybe that works in the minor leagues, but not with me.
Meg: You shot me! I can't believe you just shot me!
Denmark: May 28, 2006 on TV3
Portugal: February 26, 2007 on AXN
France: March 5, 2007 on TF6
Belgium: August 22, 2007 on VT4
Germany: March 17, 2008 on ProSieben
The Netherlands: November 23, 2008 on NET5
This episode was nominated for a Golden Reel Award for Best Sound Editing in Sound Effects and Foley for Television - Short Form.
First episode to feature a "To Be Continued..." at the end.
The town of Salvation, Iowa, is fictional.
This episode opens with "The Road So Far" - a series of clips accompanied by music showing what has happened in the season to date.
Music: Carry On Wayward Son by Kansas.
Meg: Still there, John-Boy?
Referring to the 1970s TV show The Waltons. The story is told through the eyes of John Boy, who wants to be a novelist, goes to college, and eventually fulfills his dream. The signature scene that closed each episode was the voice-overs, where each character bids the other good-night: "Good night, Mary-Ellen." "Good night, Jim-Bob." "Good night, Elizabeth." "Good night, Ben," etc., until the last good-night from John Walton, Sr. to his son: "Good night, John-Boy." "Good night, everyone." The show ran on CBS from 1972 to 1981.
Meg: Wabash and Lake.
That is the same location of one of the exits near the end of the first Matrix, albeit in a different city.