Sam and Dean allow themselves to be arrested in order to investigate a series of murders inside a penitentiary. However things get complicated when FBI agent Henricksen shows up to take over their case.
A woman named Molly and her husband are driving down the highway and swerve to miss a farmer who's walking down the road. Their car hits a tree and when Molly wakes up her husband is missing. Sam and Dean discover Molly and find out that the farmer haunts the highway and Molly is most likely his next victim. Sam and Dean set off to stop the farmer before he can claim her.moreless
Sam and Dean investigate the slayings of blonde women and find that the ghost of the first known serial killer in US history is responsible. Jo disobeys Ellen's wishes and follows them along, and is captured by the ghost.
Sam and Dean meet Andy Gallagher, a slacker with psychic powers of persuasion. Once the brothers learn that Andy’s family was visited by the Demon, Sam wonders if he could be one of the special children.
After the events at the hospital, the brothers have no idea where the demon that killed their mother is hiding. While biding their time trying to come up with an idea, they investigate murders committed by a killer clown.