To stop the Apocalypse, Dean and Sam have no choice but to make decisions that will change their lives forever... and cost them everything they hold dear.
Bobby sells his soul to Crowley in return for the location of Death. Meanwhile, Castiel must intervene when Pestilence infects the Winchesters with a deadly disease, and Dean makes a deal with Death.
To save humanity and demonkind alike, Crowley offers to help the Winchesters find Pestilence so they can get his ring. Dean must learn to trust Sam when Crowley reveals Sam has history with the Four Horseman's demon "Stable Boy."
A group of gods abduct the Winchesters and try to use them to bargain with the angels to stop the Apocalypse. However, when Gabriel arrives to warn them, one of the gods betrays the others to Lucifer.
Dean considers giving up and giving in, but Zachariah comes up with a new strategy against Lucifer that means they no longer need Dean as Micheal's vessel. However, the consequences will cause even greater destruction, and the Winchesters and Castiel must stop Zachariah before it's too late.
When Sam and Dean are killed by hunters, they end up in Heaven. They discover they must find Joshua, an angel who speaks directly with God, before Zachariah can find them.
The brothers investigate when the dead come to life in Bobby's hometown... but are happy, content, and living peacefully with their families. Bobby is reunited with his dead wife and tells them not to worry, but Sam and Dean insist on staying and discover that the zombies have an ulterior motive.moreless
The brothers take on Cupid when the people of a small town start killing each other in the name of love. However, they soon discover that a greater power is responsible.
While the brothers are on a case, Sam is targeted by a high school student who has learned a body-switching spell. Dean discovers his brother is now more interested in getting drunk and hitting on women, while Sam has to deal with the teenager's home and school life.
The brothers must go undercover as patients at a mental hospital to get at a monster, but soon discover they have some mental issues of their own to deal with.
Sam and Dean are tricked into attending a Supernatural convention by their super-fan Becky. Sam and Dean are in for a shock when many of the fans are dressed up like them.
Dean and Sam find themselves mystically trapped in a series of real-life "TV shows" and there appears to be no escape. They believe their old enemy the Trickster is responsible, but discover someone or something else is involved.
Sam and Dean investigate reports of fairy tales come to life and find the young boy who is responsible, and has a power to create real creatures from fantasy. However, the brothers disagree when Castiel tells them to kill the boy because of the power he possesses.
Sam and Dean head to a small town where people are murdered by famous dead icons. However the brothers come to a dead end when two teenagers reveal they saw Paris Hilton kidnap their friend.
Dean refuses Sam's efforts to help him battle the Devil, and then wakes up to find himself five years in the future, in a wasteland where Lucifer has begun his endgame by unleashing a virus that transforms humans into zombies.
Sam decides to stop hunting but has a hard time after he receives a surprise visit. Dean and Castiel try to find the Archangel Raphael in their bid to stop the Apocalypse.
Hunter Rufus Turner calls in Bobby, Sam, and Dean to deal with a demon infestation in his town, but they soon discover the truth is much more horrifying. Meanwhile, Castiel goes to seek the only entity that can defeat Lucifer.