To save humanity and demonkind alike, Crowley offers to help the Winchesters find Pestilence so they can get his ring. Dean must learn to trust Sam when Crowley reveals Sam has history with the Four Horseman's demon "Stable Boy."
Dean considers giving up and giving in, but Zachariah comes up with a new strategy against Lucifer that means they no longer need Dean as Micheal's vessel. However, the consequences will cause even greater destruction, and the Winchesters and Castiel must stop Zachariah before it's too late.
The brothers investigate when the dead come to life in Bobby's hometown... but are happy, content, and living peacefully with their families. Bobby is reunited with his dead wife and tells them not to worry, but Sam and Dean insist on staying and discover that the zombies have an ulterior motive.moreless
While the brothers are on a case, Sam is targeted by a high school student who has learned a body-switching spell. Dean discovers his brother is now more interested in getting drunk and hitting on women, while Sam has to deal with the teenager's home and school life.
Dean and Sam find themselves mystically trapped in a series of real-life "TV shows" and there appears to be no escape. They believe their old enemy the Trickster is responsible, but discover someone or something else is involved.
Sam and Dean investigate reports of fairy tales come to life and find the young boy who is responsible, and has a power to create real creatures from fantasy. However, the brothers disagree when Castiel tells them to kill the boy because of the power he possesses.
Dean refuses Sam's efforts to help him battle the Devil, and then wakes up to find himself five years in the future, in a wasteland where Lucifer has begun his endgame by unleashing a virus that transforms humans into zombies.
Hunter Rufus Turner calls in Bobby, Sam, and Dean to deal with a demon infestation in his town, but they soon discover the truth is much more horrifying. Meanwhile, Castiel goes to seek the only entity that can defeat Lucifer.