Supernatural Season 1 Episode 6

Dean: So the neighbor's dog went psycho right around the time Zack's girlfriend was killed.
Sam: Animals can have a sharp sense of paranormal.
Dean: Yeah, maybe Fido saw something.

Dean: Sam, the guy's walkin' around with my face. Okay, it's a little personal, I wanna find him.

Sam: What are you gonna do to me?
Shapeshifter Dean: I'm not gonna do anything, Dean will, though.
Sam: You'll never catch him.
Shapeshifter Dean: Oh, it doesn't matter. Murder in the first? Of his own brother? He'll be hunted the rest of his life.

Rebecca: What did you call it?
Shapeshifter Dean: A shapeshifter. Yeah, maybe we're crazy, but what if we're not? I mean, look, you said it yourself, that Zach was in two places at once, now tell me how that can happen?
Rebecca: Okay, so this thing, it can make itself look like anybody?
Shapeshifter Dean: That's right.
Rebecca: Well, what is it? Like a genetic freak?
Shapeshifter Dean: Maybe...evolution is about mutation, right? So maybe this thing was born Human but was different, hideous and hated... until he learned to become someone else.

Shapeshifter Dean: I must say, I will be sorry to lose this skin. Your brother's got a lot of good qualities - you should appreciate him more than you do.

Sam: We've gotta find a phone, call the police!
Dean: You're gonna put an APB out on me?

Dean: I really wish things could be different, you know, I wish you could just be Joe College.
Sam: Nah, that's okay. You know, truth is, even at Stanford, deep down, I never really fit in.
Dean: Well, that's cuz you're a freak.
Sam: Yeah, thanks.
Dean: Well I'm a freak, too. I'm right there with you, all the way.

(talking about the shapeshifter)
Dean: Argh, the thought of him driving my car.
Sam: Ah come on.
Dean: It's killing me!
Sam: Let it go.

Dean: I think we're close to its lair.
Sam: Why do you say that?
Dean: Because there's another puke-inducing pile next to your face.
Sam: Ughh, gah!

Shape-Shifter Dean: Even when we were kids, I always kicked your ass!

Dean: You know, I gotta say, I'm sorry I'm going to miss it.
Sam: Miss what?
Dean: How many chances am I going to have to see my own funeral.

Dean: All right, what are we doing here at 5:30 in the morning?
Sam: I realized something - the videotape shows the killer going in but not coming out.
Dean: So he came out the back door.
Sam: Right, so there should be a trail to follow, a trail the police would never pursue.
Dean: Because they think the killer never left, they caught your friend Zach inside. (sotto voce) Still don't know what we're doing here at 5:30 in the morning.

Sam: Hey, Bec, can we take those beers now?
Rebecca: Uh, sure.
Sam: Hey, ah, maybe some sandwiches, too?
Rebecca: What do you think this is, Hooters?
Dean: (sotto voce) I wish.

Dean: Sam wears women's underwear.
Sam: I've been listening, I'm just busy.

Dean: All right, but first I want to find that handsome devil and kick the holy crap out of him!

Dean: Man, it's not even a good picture!
Sam: It's good enough.

Dean: That better be you, Sam, and not that freak of nature!
Sam: Yeah, it's me. He went to Rebecca's, looking like you.
Dean: Well, he's not stupid. He picked the handsome one.

Shape-shifter Dean: He's sure got issues with you. You got to go to college. He had to stay home. I mean, I had to stay home, with Dad. You don't think I had dreams of my own? But Dad needed me. Where the hell were you?
Sam: Where is my brother?
Shape-shifter Dean: I'm your brother. See, deep down, I'm just jealous. You've got friends, you could have a life. Me? I know I'm a freak. And sooner or later, everybody's gonna leave me.
Sam: What are you talking about?
Shape-shifter Dean: You left. Hell, I did everything Dad asked me to and he ditched me, too. No explanation, no nothing, just poof! Left me with your sorry ass. But still, this life... it's not without its perks. I meet the nicest people! Like little Becky. You know... Dean would bang her if he had the chance. Lets see what happens.

Dean: I hate to say it but that's exactly what I'm talking about. You lie to your friends cause if they knew the real you, they'd be freaked. It's just... it'd be easier if...
Sam: ... If I was like you.
Dean: Hey man, like it or not, we are not like other people. But I'll tell you one thing. This whole gig... it ain't without perks!
(hands Sam a gun with silver bullets in it to kill the shape-shifter)

(after Dean finds out that Sam's friend, Zach, has been put in jail for murdering his girlfriend)
Dean: Dude, what kind of people are you hanging out with?!

Dean: Look, it sucks. But with a job like this you can't get close to people. Period.
Sam: You're kind of anti-social, you know that?
Dean: Yeah, you know. Whatever.