When Dean says to Doc Benton, "Please, what? You've been killing poor bastards for over 150 years.." the way his mouth is moving does not match the words he is saying.
In the opening scene, the doctor is pushed into the trunk of his car and locked in. Ever since 2002, all cars in North America have been required to have internal trunk release handles which glow in the dark should anyone become so trapped.
When Bela makes the pact with Lilith, Lilith's eyes are red instead of white.
When the jogger wakes up strapped to the table his heart monitor, while right-side-up for the camera, is now upside-down on his wrist.
Dr. Benton begins to scoop out Sam's left eye, but when Dean shoots him, his hand is at Sam's left eye-which is now red, but is back to normal in the next shot.
When Sam is attacked in the hotel room, he drops his Blackberry phone. However, the wrong screen is shown on the phone. Since he was talking on the phone we should have seen a lighter screen with the caller ID. The screen shown is the one you see when you are not using the phone.
Rufus: Do I look like I'm here to help you?
Dean: I'm gonna say no.
Rufus: Then get the hell off my property.
Dean: All right, that… Hey, fair enough. I got one more question for you though. See, I got this bottle of Scotch. Is this considered good?
Rufus: There are things that you don't know about her.
Dean: Oh and you do? Right, because you know things.
Dean: And let me guess, you lift her fingerprint?
Dean: And that got you jack.
Rufus: Yep. She burned them off. Probably years ago.
Dean: Yeah, so you're right where we are.
Rufus: Nope. You do her ear?
Rufus: You do her ear?
Dean: Hey man I'll try anything once, but I don't know, that sounds uncomfortable.
Sam: Dean, there's no way she still has the Colt. That was months ago, she probably sold it the second she got it.
Dean: Well, then I'll kill her. Win-win.
Sam: According to this, Benton's picky about where he sets up his lab. He likes a dense forest, with access to a river or stream, or some kind of fresh water.
Sam: Because that's where he likes to dump the bile, the intestines, and the fecal matter. Lost your appetite yet?
(Dean stops chewing and looks at burger)
Dean: Oh baby, I can't stay mad at you (resumes eating).
Demon: I'm telling the truth!
Dean: Oh, you are? Then let me make it up to you. (douses him in holy water)
Dean: Now I'm gonna ask you one more time: Who holds my contract?!
Demon: Your mother. Yeah, she showed it to me, right before I bent her over.
Dean: I'll see you in Hell.
Sam: I talked to Mr. Beetle's doctor. Turns out his incisions were sewn up with silk.
Dean: That's weird?
Sam: Yeah, nowadays it is, but silk used to be the suture of choice back in the early 19th-century. It was really problematic. Patients would get massive infections, the death rate was insane.
Dean: Good times.
Sam: Right. So, doctors, they had to do whatever they could to keep the infections from spreading. One way was maggots.
Dean: Dude, I'm eating.
Sam: It actually kind of worked because maggots, they eat the bad tissue and they leave good tissue. And get this. When they found our guy, his body cavity was stuffed full of maggots.
Dean: Dude, I'm eating!
Doctor: Didn't you read my report?
Dean: Of course we did. Oh, it was riveting, a real page-turner. Just delightful.
Doctor: You done?
Dean: I think so.
Doctor: Please, go away.
Doctor: Can I see your badges?
Sam: Of course. Sure.
(both show badges)
Doctor: Fine. So, you're cops and morons.
Dean: Excuse me? (stammering) No, no. We're, we're very smart.
Dean: Speaking of, what do you care about zombies?
Sam: What do you mean?
Dean: Well, you've been on soul-saving detail for months now. And we're three weeks out and all of a sudden, you're interested in some hot zombie action?
Sam: Hey, man, you're the one who's been all gung ho to hunt. I just thought I'd be doing you a favor.
Dean: Hey, no, no, no, no, no. I didn't say I didn't want to do it, okay. I mean, obviously, I want to hunt some zombies.
Sam: Okay, fine, whatever.
Sam: Remember that thing in the paper yesterday?
Dean: "Stripper suffocates dude with thighs"?
Dean: Zombies do like the other other white meat.
Dean: You make me sick.
Dean: Oh, hiya, doc. Wakey, wakey, eggs and bac-y.
Injoke: When Sam gets out of his rental SUV to investigate the hunting cabins, a sticker on the visor indicates the rental is from Lariat Car Rentals. This is a tip of the hat to The X-Files. Mulder and Scully always had Lariat Auto Rentals vehicles.
John's encounter with Doc Benton that Sam tells Dean about is detailed in the 4th issue of the comic Supernatural: Origins.
Denmark: May 18, 2008 on TV3
Latin America: May 28, 2008 on Warner Channel
UK: June 22, 2008 on ITV2
Australia: June 22, 2008 on Channel 10
Norway: September 14, 2008 on TVNorge
Spain: December 1, 2008 on AXN
Sweden: December 14, 2008 on Kanal 5
Portugal: February 12, 2009 on RTP 2
Germany: March 23, 2009 on Premiere Film
Finland: July 30, 2009 on Sub
Czech Republic: April 30, 2010 on Prima COOL
Slovakia: October 7, 2010 on Markiza
Dean: Well we can't exactly get those at a Kwik-E-Mart can we?
This alludes to the fictional chain of convenience stores included in The Simpsons television series.
Dean: Okay, great. My man Dave Caruso will be stoked to hear it.
A reference to CSI Miami, where David Caruso plays Horatio Caine, a crime scene investigator who would indeed be stoked to hear about evidence like that.
Dean: Zombie with skills. Dr. Quinn, Medicine Zombie.
Referencing the 1993-98 TV series starring Jane Seymour as the title character, a female doctor carving out a life for herself in the Wild West of the post-Civil War era. She struggles with prejudice against her gender as well as a romance with a mountain man and the raising of three orphaned children.
Dean: A little Antique Roadshow surgery, some organ theft.
Referencing the PBS series where appraisers travel the country, assessing individuals' collections and providing advice.
Dean: Ah, what is this, Sid and Nancy?
Referencing the movie Sid & Nancy (1986), which chronicles the life of Sex Pistols punker Sid Vicious and his girlfriend Nancy Spungen, and the tragic ending to their relationship.
Time Is On My Side is the name of a song by The Rolling Stones.
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