In this episode Vanilla Ice sings his hit "Ice Ice Baby".
The episode begins with a cold opening featuring a "Sarah Palin,Pro-Life,Anti-Moose" sketch.
Daniel Ramos is the actual photographer that was attacked by Britney Spears with an umbrella.
In this episode the "Comedy for Stoners" sketch is in the middle of the episode. Normally it is at the very end of the episode.
Alex Borstein says the word "vagina" five times in her interview.
Seth McFarlane closed the show by singing the Frank Sinatra song You Make Me Feel So Young.
In one sketch, Spike announced that the show is trying to appeal to audiences in other countries where the show is aired, such as Canada, Ireland and Singapore. The sketch featured a Leprechaun singing "O Canada", and simultaneously being caned by Miss Singapore.
The music that was playing at Spike's house during the "Trading Spouses" sketch was Sister Christian by "Night Ranger" and Jessie's Girl by "Rick Springfield".
The actress who played the wife in the "Trading Spouses" sketch, Dannah Feinglass, also played the "Mother" in the "Nanny 911" sketch which aired in the "Jeff Garlin" episode.
In this episode Spike showcases a large board with a photo of the main four characters of Seinfeld. On this board we see that Jerry Seinfeld and Jason Alexander are crossed off. As Spike crosses off Julia Louis-Dreyfus, Michael Richards is the only one that remains.
In "Bigfoot Opera", the final actions of the Bigfoot had to be concealed by a fuzzy dot.
The brand of beer that Cheryl Hines shotgunned was "Pitters", which was the same been brand that was featured in a beer commercial parody in episode 5031-06-120 "Carl Reiner" which aired 6 Jan 07.
When the "Nanny 911" sketch was shot, the script called for one of the boys to dress as a girl. However the boy actor was not willing to do this, so they "bribed" him by giving him a toy gun which you see him holding during the sketch.
In the "Nanny 911" sketch, when Nanny Spike is telling the family to watch television, we see that the "Electric Lincoln" sketch from the first episode of this show is playing on the TV.
In the "Nanny 911" sketch, when Nanny Spike is taking notes on a yellow notepad, we see that he has written "BOOKIE... Patriots +7, Packers +10, Denver +2, Tampa Bay -4, $700".
The actress who played Larry King's body in the "Horrifyingly Sexy Larry King" sketch was Irina Voronina the former Playboy Playmate of the Month for January 2001.
This episode also included a short flashback piece featuring Jerry Seinfeld and a telephone message featuring Julia Louis-Dreyfus.
In the "Humanimal" sketch, the panda humanimal is writer Adam Felber and the tiger humanimal is Blaire Reinhard, the Associate Producer of Music.
Dennis Rodman has a cameo appearance in the "Idiot Paparazzi" sketch. This occurs as the "Idiot Paparazzi" are seeking celebrities, however they speak to Rodman and they do not recognize him as a celebrity.
In the segment where Andy Richter visited with Spike, it is unusual to see that Andy sat at the interviewer's desk and Spike sat on the couch.