The bus arrives in Phoenix, AZ to meet newlyweds who want matching bride and groom sugar skulls tattooed on their calves. Tommy gets agitated because the couple doesn't like his sugar skull and makes him draw the design multiple times.
Thomas hires a new bus driver, Beej, who has to learn on the job. The crew meets up with a client at the Utah Test and Training Center in the Great Salt Lake Desert. Alien Dave is an alien hunter and gets a crop circle tattooed on his arm.
Amy, a new tattoo artist, arrives to join Thomas and his crew. From there, the bus travels to Salt Lake City, UT to meet up with Chris, a former Mormon who wants to get a memorial tattoo to remember his brother who committed suicide.
Thomas and Monica fly to Los Angeles and meet with a famous plastic surgeon to discuss Monica's breast augmentation surgery. Meanwhile, Tommy and Krystin drive the bus to meet up with Tommy's friend Tyson.
The bus rolls into the Bowen Ranch in El Paso, Texas to tattoo a horse portrait on a local cowboy. The next stop is Silver City, New Mexico where the crew meets up with Paulo, a descendant of Geronimo.
The bus rolls into Albuquerque and picks up Lava, a Tahitian dancer who wants to cover up the Thai words for 'faith' on her back. Thomas and Tommy convince Lava to get a giant Koi fish that covers two thirds of her back.
The bus travels to Sacramento to tattoo Heather, a voluptuous artist who used to work in a mortuary and has a collection of dead animals. Thomas completely changes the artwork she drew for her tattoo, but she ends up loving the tat.
Thomas drives the bus to Reno, NV to visit his old friend Chris at his tattoo shop, Sinister Ink. Krystin tattoos a sexy blonde's foot inside the shop, and everyone accuses Thomas of being the biggest flirt on the bus.
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