After having dreams about the future and the 4400. Now, Tom Baldwin is one of the Marked. He has got Matthew Ross's old personality. He wants Isabelle to get back her powers. Isabelle is now an adult again (her memories are back) and Richard is in prison.
Shawn and doctor Kevin Burkhoff announce that they have developed a test that can tell people whether taking promicin will cause their death. Jordan Collier is opposite to this test. He wants everyone to take promicin, so those who aren't promicin positives, will be dead. He doesn't want two kinds of people living on earth.
When Isabelle was still a baby, Richard was visited by his dead wife Lily. The sad part of it is that it was the ability of a 4400 to telepathically make others see specific people in their lives and interact with them under the belief they're real. Who exactly is Cassie?
Joel Gretsch's acting was great. It was good to see him playing a completely different character.