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Dr. Eric Topol discusses his new book "The Creative Destruction of Medicine: How the Digital Revolution Will Create Better Health Care."
Donald Trump's big announcement about the President is the top story of the night, with a counter announcement from Stephen.
Stephen gives some good advice to any Republican running for office that might want to comment on the topic of rape.
Special guest Anthony Everitt comes by to talk about Ancient Rome.moreless
Stephen looks to endorse a new pro-gun community in Idaho called The Citadel.
In "Thought For Food", the addictive properties of bread is looked at.
Special guest Neil Shubin tries to explain the Universe to Stephen.
Tonight Stephen welcomes the actor, director, producer, and writer Joseph Gordon-Levitt.
With twelve days away, Stephen continues to make his official election guesses with the focus on women.
Tom Hanks stops by to help Stephen with some tips for easyHalloween costumes.
Special guest Gov. Mitch Daniels arrives to plug his book and talk about the senatorial election in Indiana.
Tonight Stephen discusses Romney's chances of becoming President and what Obama is doing to stop that.
On "Smokin' Pole The Quest for Artic Riches", Stephen takes a look at China's interest in the Artic region.
Special guest Morrissey comes by and talks about the British Royal Family.
Dave Grohl stops by to talk about his documentary "Sound City."
The final day of Hobbit Week.
Is Stephen running for the senate seat of South Carolina?
Tonight Stephen welcomes the modern day ocean predadors explorer and expedition leader Chris Fischer.
Severe Candidate Warning. With only hours left in the 2012 campaign, both candidates are pulling out all the stops. Mitt Romney uses Colbert's Super Pac's slogan.
After being off due to Hurricane Sandy, Colbert strikes back.
In the first segment, Stephen tells the audience how they can help through the Red Cross and focuses on how Hurricane Sandy might effect the elections.
Stephen extends his generous offer to Donald Trump.
Special guest Lilly Ledbetter talks to Stphen about equality for women.moreless
A man makes love to a couch, Obama flaunts his testosterone-filled Cabinet, Kevin Garnett hassles Carmelo Anthony, and musician Ben Gibbard grows up.
Pig farmer Carl Edger Blake II tells Stephen about his quest to breed the world's best tasting pig.
Before starting his three week break,Stephen talks about the Relief Concert for those affected by Hurricane Sandy.
Stephen gets critical on the alleged abuses of First Lady Michelle Obama.
Stephen gives a heartfelt goodbye to Ham Rove and with the foundation in his honor, will be donating over $700,000 to various charities.
Special guest Sister Simone Campbell arrives and talks about her projects to help the needy and poor.moreless
On the eve of the final Presidential debate, Stephen looks at voter fraud and what some are doing to stop it.
In the second segment, Stephen comments on legalizing marijuana in New York.
Special guest Prof. Donald Sadoway comes on the show to talk about the improvement of our energy sources through new materials.moreless
Tonight Stephen looks at the celebrity endoresments of the candidates, which includes a squirrel.
A special report on Mitchell's Corn Palace and the shortage of corn is covered.
Special guest muscians The Killers arrive for an interview.
Guest is Newt Gingrich
"America Again" offends Canadians, Wall Street chucks its weakest link, Christopher Steiner reviews computer trading, and screenwriter Tony Kushner talks "Lincoln."
TONIGHT: Stephen Colbert welcomes the heavy metal band Metallica.
Oklahoma weatherman Gary England stops by.
Tonight Stephen tells his audience about the sacrifices he has had to make due to Hurricane Sandy.
On "Tip of the Hat, Wag of the Finger", Stephen looks at Momoto cameras and Billy Graham.
Special guests David Byrne and St. Vincent come on the show to perform.