The house the Huxtables lived in was very different.
The kitchen has different counters, shelves and cabinets.
Also, when Cliff and Clair are up in the bedroom, the bedding, headboard and furniture are different. The editors wanted to change it because Clair was a housewife instead of a lawyer. Also, the producers decided to use a cheap house because if the series didn't work out, they didn't want to spend money on a brownstone that would only be used for a pilot.