While Reed Richards is recovering in the Liquid Pool Unit, his hair is blonde for a few seconds.
When we first see the Hulk he's wearing red pants, when he leaves the park, his pants are blue. When he first changes to Banner, his pants are red again.
Hulk: But Hulk make girl cry.
Dr. Doom: She'll get over it.
Hulk: Longer Hulk fights, stronger Hulk gets!
Ben: Yeah, the smell's really startin' to get ta me!
Hulk: Hulk is bigger, Hulk is stronger!
Ben: Hulk is dumber, Thing is faster!
Hulk: (about Alicia) Pretty girl not belong with ugly rock creature!
Ben: So that explains your color; green with envy!
Thug: We're sorry! We didn't know it was you!
Ben: Yeah? Well in your case, ignorance ain't bliss!
Hulk: Hulk cannot be hurt!
Thing: Yeah, but Hulk can be clobbered!
The Hulk: Why pretty girls always try to help ugly rock monster?
The Thing: Because I floss, moss mouth.
The premise of Reed being sick while the rest of the FF fight the Hulk is taken from Fantastic Four #'s 25-26.
Final appearance of Alicia Masters.
The Hulk's transformations were later used for the Iron Man Hulk episode "Hulk Buster."
The injuries Doctor Doom sustained from the Thing from the episode "And A Blind Man Shall Lead Them" carry over to this episode when we first see him.
Watch out for cameos from New York City's resident superheroes, the X-Men (out of their costumes), As Rick and Johnny fly the air cycle over the city. The Scarlet Spider, a clone of Spider-man, makes a cameo appearance standing under a rooftop. So does Juggernaut, coming out of the water under a bridge.
This episode shares a similar plot to the Incredible Hulk episode "Doomed," in which Doctor Doom wants the power of the Hulk.