A suspicious death on the ship leads Chandler to launch a murder investigation, jeopardizing order and discipline on the vessel. Meanwhile, Rachel works on a more efficient cure, Alisha decodes an Immune message, and the ship heads to New Orleans.
Chandler and his team set out to find supplies and materials for Dr. Scott's lab, only to tangle with bounty hunters and the Immunes. Meanwhile, Rachel's effort to find a spreadable cure depends on the scientist who nearly erased mankind.
Chandler tries to gain intel and reverse the brainwashing suffered by Michener. Also: Rachel attempts to construct Dr. Hunter's lost formula while wrestling with the knowledge that her bitter enemy is now on board the Nathan James.
Chandler and his team infiltrate an Immune compound. Danny poses as one of Ned's workers and discovers that Patient Zero is working for the Ramseys. Meanwhile, Chandler inches into Sean's inner circle.
Chandler tracks the Immunes to Northern Florida in a bid to avenge the destruction of the labs. Elsewhere, Rachel unearths a secret yet incomplete cure formula, and Chandler's team locates an Immune compound controlled by Sean and Ned.
Chandler and his crew duel against rogue British naval officers manning a nuclear-powered submarine. Meanwhile, Slattery interrogates a mercenary to learn more about a hospital ship, and a dangerous game of cat-and-mouse ensues.
Chandler sees an opportunity to add another vessel to the fleet when a hospital ship is discovered at sea waiting for Dr. Scott's cure. But tensions rise when Chandler and his team board the ship, only to face an unforeseen enemy.
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