The League reminds me of Spike TV's Factory, which briefly aired in the summer of 2008. Not well-known, but established male comedians at the forefront and then these random, lifeless women in the background. While the males tend to get the better lines in sitcoms it is extremely vital to have strong female characters as well, not just to attract viewers, but to balance the show out. Would Seinfeld have been as successful without Julia Louis Dreyfuss, or could 30 Rock work with a man instead of Tina Fey?
The League is also similar to Factory in that the quality is pretty poor. A good line here, a nice remark there, but just about every joke fell really flat. The show kept switching between being raunchy and then trying to replicate It's Always Sunny in Philadelphia. The show has no identity, it's the Dr. Pepper of television, except Dr. Pepper is actually good.
I also have to question whether or not a lot of people would get the football references. Does the average American know who Matt Forte is?
For The League to be successful they need to bring in a funny female to the cast, tone down on the raunchy humor and focus on football, but do it in a way where people who are not huge fans of the sport can also enjoy it (see Friday Night Lights).