The oulaws' anger at Wyatt Earp comes to a boil. Marshal Earp turns down the offer of help from the town's vigilantes and decides that it will be just him, his two brothers, and Doc Holliday who will face down Ike Clanton and the other outlaws at the O.K. Corral.
Tim Connell, Doc Holliday's brother-in-law, arrives in Tombstone. Doc recommends that Wyatt take him on as a deputy, but things go bad when Tim's wife Martha convinces Tim to frame Doc as revenge for Doc divorcing her sister Kate.
Two fatherless children decide that they want Shotgun Gibbs as their new father when he chases off their mother's unwanted suitor.
Tom McLowery and his wife move into Tombstone over brother Frank's objections, and Old Man Clanton puts the McLowerys in charge of the OK Corral so he can set up a base of operations under Wyatt's nose.
On a trip to the capital, Wyatt finds a baby who is the only survivor of an Apache attack. He ends up taking care of the baby when he can't find anyone to take it in.
Saloon owner Lou Rickabaugh brings in his niece Edith to boost business with her poetry, but a rival saloon owner resents the competition and takes steps to eliminate his rival.
When Sheriff Behan rips off Johnny Ringo and Curly Bill Brocius, they recruit Doc Holliday to help them when Old Man Clanton refuses to punish Behan. Doc is glad to help out on behalf of Wyatt, and figures what his friend doesn't know won't hurt him. They successfully frame Behan, but Wyatt is suspicious of the frame-up.moreless
Wyatt gives ex-convict Jed Lorimer a second chance. But Jed has trouble sticking to the straight and narrow when his girlfriend's brother Phil get into trouble over money he owes to Dapper Courtney. Courtney wants Phil to recruit Jed to steal a mining payroll in return for forgiving his IOUs.
Chief Natchez appeals to Wyatt for help when outlaws impersonate Apaches and frame the Indians for crimes they didn't commit.
When Emma Clanton returns to Tombstone, her father is determined to marry her off to Wyatt... whether she wants to or not.
It's a war of words when the 10 Percent Gang uses the Tombstone Nugget to discredit Wyatt and Shotgun when Shotgun's mule Roscoe is accused of kicking a young boy.
Old Man Clanton's new scheme to sell whiskey to the Apaches in return for information on a hidden cache of gold. However, it backfires when the Indians capture Phin Clanton and Wyatt has to help out.
When Doc Holliday's condition gets worse, Wyatt tries to save his friend's life by secretly watering down his whiskey. Since he can't get solace from whiskey anymore, Doc decides to go out fighting by calling out the McLowery brothers.
A group of robbers who disguise themselves using clown costumes and masks arrive in Tombstone.
Johnny Behan falls for Minna Marlin, a traveling actress, but he makes the mistakes of telling her too much about the Clantons and they come looking for revenge.
Doc Holliday's luck turns and he takes $15,000 in poker and doubles it buying a mine, and then triples it investing in railroad stock. He sets out to buy a hotel, the Holliday House, and cuts Wyatt in for 20%. However, Doc's luck soon turns bad when robbers go after the remaining money and Wyatt has to make a deal in return for their testimony.moreless
Wyatt ends up saving Old Man Clanton's life and the outlaw reluctantly offers the marshal a job to clear his debt. When Wyatt refuses, Clanton is left owing him a debt... and gets a chance to repay him when the Ten Percent Gang bribes witnesses to slander Wyatt.
Tom Grover is framed by Sheriff Behan for a crime he didn't commit and sentenced to Yuma Prison, and Tom's wife Beth goes to Wyatt for help.
When Wyatt arrests the McLowerys, Old Man Clanton refuses to help them. When Behan releases them, Billy gets revenge on Wyatt by stealing his horse.
Someone takes a shot at Billy Buckett, creases him on the head, and takes $50,000 that he got from prospecting.
Morgan Earp's fiancée Ruthie leaves him when he gets full of himself on a winning streak. Wyatt convinces her to come back and hires a card sharp to break Morgan's streak... but the card sharp has a plan of his own.
Sadie Roberts brings her husband, bank robber Ben Roberts, into Tombstone for treatment for an injury. There's no warrant on his arrest and Wyatt isn't interested in bringing him in. However, Ben's gang of bank robbers figure that Tombstone is the perfect target for them.
Johnny Ringo decides to turn over a new leaf for the love of a good woman, Mary Turner. However, Mary's brother Claude doesn't want his sister married to an outlaw, and Old Man Clanton doesn't want to lose his best gunslinger.
A killer is loose in Tombstone, and he or she is trying to make the murder look like an accident by injecting the victim with an air bubble from a syringe.
Wyatt sets out to help a man who is suffering from mental illness. During one of his spells, he wounds two Texas Rangers and his brother vows to protect him no matter what.
Odie Cairns becomes violent when a True Lighter couple pass through Tombstone, threatening to drive them out of town because of a massacre that cost his family his life.
Ned Buntline returns to Tombstone in disguise, fooling no one. Wyatt soon discovers that a woman wants revenge for the death of her husband... and she's willing to blackmail Wyatt to do it, by faking his signature on incriminating papers. Meanwhile, the Ten Percent Gang goes after the widow and Wyatt has to protect her, and Ned when he falls in love with the woman.moreless
Morgan Earp falls in love and proposes marriage to Lucy Tedder. However, things go bad when Lucy's husband arrives in Tombstone.
Sheriff Johnny Behan gets caught in the middle when his paymaster, Old Man Clanton, makes a move on Wyatt against Behan's advice.
A new law-and-order governor gives shoot-to-kill orders against all outlaws, and then appoints Morgan Earp as his brother's Wyatt deputy... against Wyatt's wishes.
Doc picks up a follower, Johnny O'Rourke, who soon becomes obsessed with the gambler's lifestyle and decides to emulate it... at the cost of his fiancee and possibly his life.
When Doc Goodfellow is wounded in a gunfight on the streets of Tombstone, Wyatt has to seek out a retired doctor. Unfortunately, the man has fallen victim to "gold fever" and refuses to abandon his stake to help Goodfellow.