While Him is watching the Powerpuff Girls fight a monster, he notices that Blossom and Buttercup get into an argument and that Bubbles is bothered by their fighting. He comes up with a plan to break up the Powerpuff Girls, by using Bubbles. He pretends to be the voice of Bubbles's toy, Octi and starts talking to her about who should be leader. He tells Bubbles to tell Buttercup that she should be in charge and should fight the way she wants to fight. This only provokes the fight and Blossom and Buttercup fight so much that they get sentenced to a timeout. Bubbles asks Octi for more help, only to find out that it was all a trick. Octi/Him grows in size and goes out to destroy Townsville. Bubbles tries to stop him by herself, but Octi/Him traps her in his tentacle. Bubles's screams are heard by Blossom and Buttercup, who forget their quarrel and save her.
The Ameoba Boys desperately try to get the Powerpuff Girls to see them commit a crime, but it doesn't work. They then find a "Keep off the grass" sign in the park. They stand on the grass all night, trying to break the law. But, there's a rain storm that night and they catch a cold. But the cold mixes in with their single-cell anatomy to create a new virus. They then go around Townsville, spreading their contagious cold. The Powerpuff Girls notice this and try to help the sick citizens of Townsville, but the Ameoaba Boys try to get their attention so they can show the girls that they can commit a crime. Buttercup gets annoyed and angry, so she kicks them out of town. The Powerpuff Girls then get the sickness and go seem the Professor to see if he knows anything about the virus. They find out that the Ameoba Boys are thye ones who created this sickness...and that they are the only ones who have the antidote within them. The Powerpuff Girls try to locate the Ameoba Boys before they leave, but they pass out trying to find them. The Ameoba Boys find them instead, lying in the middle of the road. Blossom explains the situation to the Ameoba Boys, but the Ameoba Boys wont go with them without a fight. They fight (it was easy, they were all so weak that they didn't fight with their usual strength) and the Ameoba Boys hsave the antidote taken from them, curing eveyone in Townsville. The Ameoba Boys are set free, confused because they thought they were locked up in a jail-like cell. But, they are let free and are upset due to that fact they they can't even get in jail!