Homer Simpson, Grampa Simpson, Barney Gumble, Krusty the Clown, Groundskeeper Willie, and others
Apu Nahasapeemapetilon, Moe Szyslak, Chief Wiggum, Comic Book Guy, Lou, and others
Mr. Burns, Ned Flanders, Principal Skinner, Waylon Smithers, Kent Brockman, and others
Marge Simpson, Patty Bouvier, and Selma Bouvier
Bart Simpson, Nelson Muntz, Ralph Wiggum, Todd Flanders, and others
Lionel Hutz, Troy McClure and Additional Voices
Maude Flanders, Helen Lovejoy, Miss Hoover, and others
When Marge is in the bowling store there is a picture of Jacques on the wall from the Season 1 episode "Life on the Fast Lane."
This is the first episode that Wiggum has blue hair.
Marge's train stops at Shelbyville, Badwater, Cattle Skull, and Testing grounds before stopping at Rancho Relaxo.
The bus driver wears a Skoal tobacco cap.
The police tape reads: ''Distressed Mother - Please Stay Back''.
The giant Olmec Indian head from the season 2 episode "Blood Feud" is still in the basement.
When Maggie crawls down one street, a car is parked in a ''No Parking'' zone.
The bus on Springfield bridge is filled with actors in costume.
Radio: This is Coma - WKOMA, restful, easy listening. Coming up next, a super set of songs about clouds.
Troy: I'm Troy McClure. You might remember me from such movies as "Today We Kill, Tomorrow We Die" and "Gladys the Groovy Mule." But today you'll see me in my greatest role - your video tour guide to Rancho Relaxo!
Marge: Thanks again for taking the children while I'm away.
Selma: Don't worry yourself.
Patty: We've got six months of maternity leave we're never going to use anyway.
Marge: I need to unwind.
Homer: I know you do, Marge, but come on, you know what our vacations are like. Those three monsters in the back seat: "Are we there yet? Are we there yet?" And let's face it; I'm no day at the beach either: "Marge, can I have another sandwich? Marge, can I have another sandwich?"
Eddie: She's locked in the car and refuses to move.
Chief Wiggum: Did you flash your lights?
Chief Wiggum: Well, I'm fresh out of ideas.
Arnie: This is Arnie Pie with Arnie in the Sky. We've got big problems on the Springfield Memorial Bridge, people. Traffic going waaaay back in both directions. And look out at the corner of 14th and Elm, because I just dropped my bagel.
Lisa: Mom, Bart's making faces at me.
Bart: It's a nervous twitch, and I'm a little sensitive about it, if you don't mind.
Selma: Come on kids! Time to rub Aunt Patty's feet!
(Bart and Lisa shudder)
Homer: Hi Barney, thanks for keeping me company!
Barney: No problem...well, well, if it isn't little Bart! Remember me, your uncle Barney! Hey Homer let me hold him.
Homer: Alright, but just be careful!
Barney: Whoa! Someone smells stinky! Oh it's me!
Selma: Bart, you'll be sleeping with your Aunt Patty.
Bart: In your bed?
Patty: Uh huh, and I shall warn you, I'm told I snore.
Homer: Let me through, let me through! I'm her husband!
Eddie: Well, that explains a lot!
Bus Driver: Look lady, this better be good....
Marge: (Starts roaring like a tiger...the driver goes back in the bus)
Radio: It's time for another Bill and Marty Classic Prank Call!
Bill: Hello is this Mr. Chester Sherman?
Bill: Sir your wife is dead!
Chester: Oh...god, no!
Bill: That's right, she just walked through a plate glass window, there's blood everywhere!
Chester: But...but I just talked to her (starts crying)
Homer: Barney! I lost the baby! What am I going to do!?
Barney: Don't worry. Don't worry. Know what I'm going to do? I'm going to make you an omelet.
Homer: Just help me look.
Barney: Are you sure? I make 'em with four kinds of cheese.
When Marge leaves for her vacation there is a man on the train platform checking his watch. He is modeled after Mark Kirkland who wrote this episode.
There were some scenes in the trailers for this episode which didn't make it to air. After Homer staples Maggie's diaper shut, he picks her up, and the changing board comes with her.
Blackboard Joke: I will not spank others.
Couch Gag: The family forms a pyramid.
The look on Homer's face (mouth wide-open with hands touching face) is a parody of the famous expression shown on Macaulay Culkin's face, the star of Home Alone (1990). The title of the episode is also an obvious parody of the film's title, which spawned three sequels.
BART (Brat'us Don'thaveacow'us) HOMER (Homo Neanderthal'us)
The opening sequence is taken right out of the classic Warner Bros cartoons featuring the Road Runner and Wile E. Coyote (Genius).
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