The writing on the side of the altar in the final scene is in the runes from J. R. R. Tolkien's The Hobbit. An approximate transliteration is "Chris Beelmen a tonia Jesus Christ".
Among the Psychiatrists at Marge's insanity hearing, is what seems to the young Dr. Foster, seen in the flashbacks of the episode "Hurricane Neddy."
When Marge was escaping the police by disguising herself as a band member in a parade, the closed captioning has the lyrics, "They're coming to take me away, ha-ha, they're coming to take me away, ho-ho, hee-hee, ha-ha, to the funny farm". But the lyrics were never sung.
Skinner: Now kids, be creative with your video projects. I don't want to see twenty Blair Witch knock offs.
Marge: Becky, I'm so sorry I accused you of trying to kill me and steal my family.
Becky: Hey, no biggie. I was trying to steal your family. I even thought of a good place to bury you. Then I didn't have a shovel so I went to the hardware store and they had six different kinds, and I was like, "Later!"
Bart: The kids are saying if you say "Bloody Margie" five times, she'll appear. But then she gouges your eyes out!
Homer: I hear she mates with men, then eats them!
Homer: What are these things in the mashed potatoes?
Becky: That's the skins. I left them on.
Marge: Nobody's perfect, let me just pick thos…
Homer: No! Oh Becky…your potatoes are the best I've ever had! Oh, God!
Bart: So, any words for the bride and groom?
Skinner: Not now, Bart! I'm trying to urinate.
Bart: You don't seem to be trying very hard.
Bart: Otto, a red traffic light means what?
Otto: No time for brainteasers. Today's the day I ask my girlfriend to take a ride on the matrimony pony!
(recording Lisa on a video camera)
Bart: Tonight, on the Discovery Channel…inside Lisa's nose. What will we find? Boogers or Nazi gold?
Lisa: Bart, quit it!
Bart: No way.
Lisa: Bart sleeps with Raggedy Andy!
Bart: Cut, cut, cut!
Nelson: Stop hitting yourself: take 1. Stop hitting yourself!
Nelson: Stop hitting yourself!
Nelson: Stop hitting yourself!
Otto's Father: Your mother and I don't approve of this marriage, as we have not approved of any of your life to date.
Otto: Well the important thing is, you came…
Otto's Father: We're leaving…
Otto: Drive safe!
Marge: Maybe I am crazy. After all, I am talking to myself.
Hans Moleman: You are? Ohh. I thought I'd made a friend.
Milhouse: Otto's got a girlfriend! Otto's got a girlfriend!
Otto: That's right, I do.
Milhouse: Uh, I know you do... baby!
Marge: Let's see... candles, flowers, place cards, rice--
Lisa: Oh, Mom, you're not supposed to throw rice anymore. Birds eat it, their stomachs swell, and they explode.
Bart: Why am I just learning this now?
(He grabs the rice box and video camera then runs outside.)
Marge: Don't mess with me! I've got Jimmies!
(She throws jimmies in the eyes of ice cream employees)
Employee: I only see a horrible rainbow!
Homer: Becky, I think I speak for all of us when I say, "When's the ice cream going to get here?"
Marge: Why do I always think of the perfect thing to say when it's too late? "Shut up, Becky!" Oh, that would have been sweet.
Marge: I thought the law was powerless!
Chief Wiggum: Powerless to help you, not punish you, Take her away boys. Mmm... earned my treat.
Psych #1: Excuse me, what are you doing?
Marge: Oh, I was just praying to God that you'll find me sane.
Psych #1: I see. And this "God," is he in this room right now?
Marge: Oh, yes. He's kind of everywhere.
(The psychologists exchange disapproving looks)
Psych #2: Marge Simpson, you give us no choice but to declare you utterly--
Marge: I'm not insane!
Psych #2: You didn't let me finish... Insane!
Marge: This isn't over Becky, I know where you live. My house!
Homer: Run, Marge, Run! Pump those crazy legs!
This episode originally aired as part of a Fox promotion called "The Mother of all Sundays", featuring episodes about mothers.
The line-up consisted of
Futurama "Mother's Day" - A story about Mom, the creator of all robots.
King of the Hill "Transnational Amusements Presents: Peggy's Magic Sex Feet"- A sleazy man puts Peggy's feet on the Internet.
Simpsons "It's a Mad, Mad, Mad, Mad, Marge" - Marge thinks Otto's ex-girlfriend is trying to take her place in the family.
Malcolm in the Middle "Smunday" - A high fever makes Lois think Monday is actually Sunday.
Blackboard Joke: I cannot hire a substitute student.
Couch Gag: Korean animators come and paint the family by numbers.
At Otto's wedding, Patty and Selma are talking to Lisa about how guys are pigs, and Patty says "The bitterness is strong in this one." This is an allusion to Star Wars: A New Hope, when Darth Vader says "The force is strong with this one," about Luke Skywalker.
Krusty shows a picture of Marge with mouth of somebody else who is making jokes- this sketch is very familiar to the ones in Conan O'Brien's late night talk show.
The outfit Becky wears at the end looks very similar to Vamperilla of comic book fame. The differences are that Vamperilla's outfit shows a lot more skin and the logo is in a different place.
This title is taken from the classic 1963 film comedy It's a Mad Mad Mad Mad World.