When drawing God, the animators always give Him five fingers. But if you play the scene where God is pulled out of the universe in slow motion, you can see He does indeed have five fingers on each hand, but only four toes on each foot.
We learn that Kang and Kodos have a secretary named Dorothy.
Martin: (As Oberon, King of the Fairies) I'm telling you, I'm Oberon, King of the Fairies!
Groundskeeper Willie: (As a can of Bug Spray) You're a big, fat bug. And you're going down! (Sprays Martin).
(Dr. Hibbert has become a vampire and offers to fly Abe to the hospital.)
Abe: That's it, suck out the poison. Wait a minute…aaaaahhhhh!
Witch: I'm a real witch.
Carl: Wait a minute that's cheating!
Sideshow Mel: Burn her!!!..........Gift certificate!
Lenny: I see heaven!
Carl: What does it look like?
Carl's Angel: Hurry up Lenny; you'll be late for work at the plant!
Carl: Burns has only been chasing us six hours and you've already resorted to cannibalism.
Lenny: And there's bananas in that tree up there.
Homer: Eh, they look a little green.
Bart: Dad gets to kill wild animals, but I shoot one bird and I had to go to a psychiatrist.
Marge: Hmm, he still thinks that hobo was a bird.
Carl: This is a pretty sweet deal, Burns inviting us over. What kind of motive do you think he has?
Terry Bradshaw: Well, coventional wisdom says good fleeing will always beat good chasing, but the stats say put your money on the guy with the gun!
Lawyer: (at Burns' people hunt) Excuse me, what gives you the legal right to do this?
Mr. Burns: You tell me; you're my lawyer.
Lawyer: Well, I guess you are zoned for hunting, and you have previously claimed killing people as part of your religion. I think I can draw something up.
Mr. Burns: The game I'm hunting is all of you. Now because I'm too kind, I'll give you all a five minute head start. You may commence running.
Comic-Book Guy: Five minutes of running? Shoot me now.
Bart: You replaced me with this tinkertoy?!
Homer: "Replaced" is such a harsh word. We upgraded.
Mr. Burns: I smell fear… and curry.
Apu: (in bushes) Uh-oh.
(Mr. Burns shoots the bushes and Apu pops out.)
Apu: You got me, but I shall be reincarnated.
(Apu dies and reincarnates into a rabbit.)
Rabbit Apu: Ha, ha… you can't kill a Hindu!
(The rabbit runs through a bear trap and the tail gets caught.)
Rabbit Apu: Ahh! Help me Jesus!
Moe: This concludes this year's Halloween show. We hope you had as much fun watching our show, as the Koreans did animating it.
Bart: I'm not a robot, I'm a human.
Robot: Human? Tell me, what is it like to have feelings?
Bart: I said I was human, not a girl.
(Marge hits Homer in the head with a frying pan)
Homer: Oww! What was that for?
Marge: That was for staying out for eighteen hours without calling me!
Homer: Oh, I can't stay mad at you...when that pan smells like sausage and onions.
Homer: Honey, animals don't feel death. That was proven by the scientists at Black Angus.
Yeardley Smith is credited as "The Lizard Queen," which is what an intoxicated Lisa called herself in "Selma's Choice".
During this episode's credits, producer Al Jean wrote his name as Al "Family Guy" Jean. And during the opening of the Family Guy episode that aired later, Stewie ran over Homer in a way similar to when Marge narrowly misses him in their garage during the Simpsons opening.
Buffy the Vampire Slayer
The "I've Grown a Costume on Your Face" segment is an allusion to the Buffy the Vampire Slayer episode "Halloween" in which all the characters turn into the costumes they are wearing.
In the robot junkyard where Bart gets dumped, there are two robots playing "Rockit" by Herbie Hancock who bear a striking resemblance to the robots from the music video of the same name.
My Fair Lady
The segment title "I've Grown A Costume On Your Face" parodies the title of the song "I've Grown Accustomed to Her Face" from the musical My Fair Lady.
The scene where Maggie flies her brown against/into the moon is a parody (or homage) to the opening credits of the television series Bewitched, complete with a few seconds of the theme music.
AI: Artificial Intelligence
The segment "BI: Bartificial Intelligence" is obviously a parody of the film AI: Artificial Intelligence, both in title and basic plot (including the android named David).
The Most Dangerous Game
The segment "Survival of the Fattest" is based on the story The Most Dangerous Game by Richard Connell.