The Skull Man is an animated horror science fiction TV series developed by Studio BONES based on Shotaro Ishinomori's manga series of the same name that follows orphan Hayato Mikogami, a twenty-three year-old reporter who wishes to make a name for himself by getting a story on Otomo City's infamous and mysterious Skull Man. It seems that his old hometown has become host to a strange man wearing a skull shaped mask with superpowers and deadly weapons. This Skull Man has been killing a number of people, typically the ones taking a nightly stroll. As Hayato and his sixteen-year-old photographer, Kiriko Mamiya, they begin to piece together a deeper conspiracy involving a pharmaceutical company, a creepy religious sect, and bloodthirsty half-human, half-animal creatures. Even more surprising, Hayato and Kiriko discover just who or what Skull Man is as the ramifications of a long ago catastrophe comes back to bite them all in the butt.